Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail
| Autor: | Narinder Dev Gupta, Ashish Agarwal, Avikal Jain |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Blood Platelets
Male Bone Regeneration medicine.medical_treatment Alveolar Bone Loss Dentistry Alveolar crest 03 medical and health sciences 0302 clinical medicine Double-Blind Method Periodontal Attachment Loss Alveolar Process medicine Humans Periodontal Pocket Gingival Recession General Dentistry Saline Gingival recession Fibrin Bone Transplantation Bone allograft business.industry 030206 dentistry General Medicine Middle Aged Allografts medicine.disease Chronic periodontitis Platelet-rich fibrin Resorption Radiography Clinical trial Freeze Drying Treatment Outcome 030220 oncology & carcinogenesis Chronic Periodontitis Guided Tissue Regeneration Periodontal Female Tissue Preservation medicine.symptom business Follow-Up Studies |
| Zdroj: | Acta Odontologica Scandinavica. 74:36-43 |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.3109/00016357.2015.1035672 |
| Popis: | Polypeptide growth factors of platelet rich fibrin (PRF) have the potential to regenerate periodontal tissues. Osteoinductive property of demineralized freeze-dried bone allograft (DFDBA) has been successfully utilized in periodontal regeneration. The aim of the present randomized, split mouth, clinical trial was to determine the additive effects of PRF with a DFDBA in the treatment of human intrabony periodontal defects.Sixty interproximal infrabony defects in 30 healthy, non-smoker patients diagnosed with chronic periodontitis were randomly assigned to PRF/DFDBA group or the DFDBA/saline. Clinical [pocket depth (PD), clinical attachment level (CAL) and gingival recession (REC)] and radiographic (bone fill, defect resolution and alveolar crest resorption) measurements were made at baseline and at a 12-month evaluation.Compared with baseline, 12-month results indicated that both treatment modalities resulted in significant changes in all clinical and radiographic parameters. However, the PRP/DFDBA group exhibited statistically significantly greater changes compared with the DFDBA/saline group in PD (4.15 ± 0.84 vs 3.60 ± 0.51 mm), CAL (3.73 ± 0.74 vs 2.61 ± 0.68 mm), REC (0.47 ± 0.56 vs 1.00 ± 0.61 mm), bone fill (3.50 ± 0.67 vs 2.49 ± 0.64 mm) and defect resolution (3.73 ± 0.63 vs 2.75 ± 0.57 mm).Observations indicate that a combination of PRF and DFDBA is more effective than DFDBA with saline for the treatment of infrabony periodontal defects. |
| Databáze: | OpenAIRE |
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