| Autor: |
Lior Fuchs, Karin Mausner-Fainberg, Anna Luban, Susanna Eva Asseyer, Maya Golan, Moshe Benhamou, Ilan Volovitz, Keren Regev, Ifat Vigiser, Yoav Piura, Hadar Kolb, Friedemann Paul, Arnon Karni |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Neuroimmunology. 371:577936 |
| ISSN: |
0165-5728 |
| DOI: |
10.1016/j.jneuroim.2022.577936 |
| Popis: |
Connective tissue growth factor (CTGF/CCN2) is a proinflammatory and an oligodendrocyte-differentiating blocking agent. It is found in MS lesions, which raises the possibility of involvement in MS pathogenesis. We found that its CSF and serum levels were higher in RR-MS patients than in controls and for serum compared to PP and SP-MS. Immune cells of both RR-MS and controls secreted CTGF/CCN2, which was enhanced by CD3/CD28 stimulation or by LPS. Anti-CTGF treatment of mice with experimental autoimmune encephalitis ameliorated its clinical severity. CTGF/CCN2 may play a role in the immune pathogenesis of MS and in remyelination failure in early stages of MS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect