Longitudinal Analysis of Quadriceps Muscle Strength in Patients with Previous COVID-19 Hospitalization and in Patients with Post-Acute Sequelae following Mild COVID-19
| Autor: | Anouk A. F. Stoffels, Esther L. van Voorthuizen, Hieronymus W. H. van Hees, Jeannette B. Peters, Hanneke A. C. van Helvoort, Nicol C. Voermans, Jonne Doorduin, Bram van den Borst |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Muscle Weakness
Nutrition and Dietetics COVID-19 post-COVID syndrome muscle weakness myopathy rehabilitation Other Research Radboud Institute for Health Sciences [Radboudumc 0] Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] Quadriceps Muscle Hospitalization All institutes and research themes of the Radboud University Medical Center Disease Progression Humans Muscle Strength Food Science |
| Zdroj: | Nutrients; Volume 14; Issue 20; Pages: 4319 Nutrients, 14 Nutrients, 14, 20 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14204319 |
| Popis: | Muscle weakness is a prominent symptom in post-acute sequelae of COVID-19 (PASC). However, few studies have objectively and longitudinally assessed muscle strength after varying COVID-19 severity grades. This observational study aimed to explore the prevalence, determinants, and 1.5 years change of quadriceps muscle weakness in 98 patients discharged from COVID-19 hospitalization and in 50 patients with PASC following mild COVID-19. Isometric quadriceps maximal voluntary contraction (MVC) was assessed on a computerized dynamometer at three visits. Also, in a subgroup of 14 post-COVID-19 patients with quadriceps muscle weakness, muscle thickness and echo intensity were determined by muscle ultrasound of nine upper and lower extremity muscles. Muscle weakness was found in 59% of post-hospitalized patients and in 65% of those with PASC following mild COVID-19 at ~14 weeks after acute COVID-19. Whereas during ~1.5 years follow-up MVC modestly improved, muscle weakness prevalence remained unchanged. Hospital length of stay and diabetes mellitus were identified as possible predictors of muscle weakness following COVID-19 hospitalization. No predictors could be identified in those with PASC following mild COVID-19. Ultrasound outcomes revealed no large structural abnormalities. In conclusion, clinically relevant muscle weakness is common after COVID-19 and its long-term improvement is poor. Future studies with relevant control groups are warranted to confirm our data. |
| Databáze: | OpenAIRE |
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