Outcome of Mood Stabilizer Discontinuation in Bipolar Disorder After 5 Years of Euthymia
| Autor: | Samir Kumar Praharaj, Sreejayan Kongasseri, Podila Satya Venkata Narasimha Sharma |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Bipolar Disorder Time Factors medicine.drug_class Drug Administration Schedule Young Adult Recurrence mental disorders medicine Humans Pharmacology (medical) Prospective Studies Bipolar disorder Young adult Prospective cohort study Psychiatry Survival analysis Aged business.industry Mood stabilizer Middle Aged medicine.disease Confidence interval Discontinuation Psychiatry and Mental health Treatment Outcome Withholding Treatment Time to recurrence Female business Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Journal of Clinical Psychopharmacology. 34:504-507 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/jcp.0000000000000160 |
| Popis: | Objective: The objective was to study the outcome of mood stabilizer discontinuation on recurrence in patients with bipolar disorder after at least 5 years of euthymia. Methods: Twenty-three patients diagnosed with bipolar affective disorder according to the International Classification of Diseases, 10th Revision Diagnostic Criteria for Research, receiving mood stabilizer prophylaxis or at least 5 years, had undergone planned discontinuation, and the rates and time to recurrence were studied. Results: Twenty (87%) of 23 patients had recurrence, and all of the episodes were manic. Kaplan-Meier survival analysis showed median time to recurrence following discontinuation of mood stabilizer prophylaxis was 10 months (SE, 6.06 months; 95% confidence interval, 0 to 21.89 months). Conclusion: Four fifths of our patients had recurrence following discontinuation of mood stabilizer prophylaxis within 10 months. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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