Quantifying Protein Function Specificity in the Gene Ontology

Autor:	Brenton Louie, Silas Bergen, Eugene Kolker, Roger Higdon
Rok vydání:	2010
Předmět:	function specificity Genetics Protein function protein annotation Gene ontology Function (mathematics) Computational biology protein function Biology Protein Annotation Similarity (network science) Standard Operating Procedures Strengths and weaknesses
Zdroj:	Standards in Genomic Sciences
ISSN:	1944-3277
DOI:	10.4056/sigs.561626
Popis:	Quantitative or numerical metrics of protein function specificity made possible by the Gene Ontology are useful in that they enable development of distance or similarity measures between protein functions. Here we describe how to calculate four measures of function specificity for GO terms: 1) number of ancestor terms; 2) number of offspring terms; 3) proportion of terms; and 4) Information Content (IC). We discuss the relationship between the metrics and the strengths and weaknesses of each.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf164ae0f1200e1f6bffbf5dc39943b https://doi.org/10.4056/sigs.561626 Zobrazit plný text záznamu Full text from SpringerLink