Influence of sickle cell disease on susceptibility to HIV infection
| Autor: | Eva Operskalski, Elliott Vichinsky, Recipient Epidemiology, Daniel M. Chafets, Tzong-Hae Lee, John W. Heitman, Michael P. Busch, Sheila M. Keating, Ward Hagar, Mars Stone, Philip J. Norris, Shannon Kelly, Brian Custer, Evan S. Jacobs, Melanie Dimapasoc |
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| Přispěvatelé: | Mummidi, Srinivas |
| Rok vydání: | 2020 |
| Předmět: |
Male
Epidemiology HIV Infections Disease CD38 Pathology and Laboratory Medicine 0302 clinical medicine Immunodeficiency Viruses Animal Cells Prospective Studies Young adult Aetiology Innate Immune System education.field_of_study virus diseases Sickle Cell Blood Medical Microbiology HIV epidemiology Viral Pathogens Medicine Infectious diseases Cytokines HIV/AIDS Cellular Types Infection Anemia Science Immune Cells T cell Immunology Microbiology 03 medical and health sciences Clinical Research Humans Blood Transfusion education Microbial Pathogens Retrospective Studies Blood Cells Transfusion Medicine Organisms Biology and Life Sciences Transfusion Reaction Molecular Development medicine.disease 030104 developmental biology Developmental Biology RNA viruses 0301 basic medicine CD4-Positive T-Lymphocytes Physiology CXCR4 White Blood Cells Risk Factors Immune Physiology hemic and lymphatic diseases Medicine and Health Sciences 2.1 Biological and endogenous factors Multidisciplinary T Cells Recipient Epidemiology and Donor Evaluation Study Hematology Middle Aged Clinical Laboratory Sciences Body Fluids medicine.anatomical_structure Infectious Diseases Viruses Female Disease Susceptibility Pathogens Anatomy Research Article Adult congenital hereditary and neonatal diseases and abnormalities Adolescent General Science & Technology Blood Safety Population Anemia Sickle Cell Viral diseases Blood Plasma Cell Line Young Adult Rare Diseases Acquired immunodeficiency syndrome (AIDS) Diagnostic Medicine Retroviruses medicine cardiovascular diseases Sickle Cell Disease business.industry Lentivirus HIV Cell Biology Protective Factors Immune System business 030215 immunology |
| Zdroj: | PloS one, vol 15, iss 4 PLoS ONE PLoS ONE, Vol 15, Iss 4, p e0218880 (2020) |
| Popis: | People with sickle cell disease (SCD) are reported to have low rates of HIV infection, slower progression to AIDS and lower HIV-associated mortality compared to the general population. Mechanisms of potential resistance to HIV in SCD are incompletely understood. We retrospectively reviewed the Transfusion Safety Study to compare HIV status between people with SCD and other congenital anemias who were routinely exposed to blood products during the high-risk period before HIV screening implementation. Non-SCD congenital anemia diagnosis was associated with a higher risk of HIV acquisition compared to SCD (OR 13.1 95%CI 1.6-108.9). In addition, we prospectively enrolled 30 SCD cases and 30 non-SCD controls to investigate potential mechanisms of resistance to HIV in SCD. CCR5 and CCR7 expression was lower and CD4 expression was higher on CD4+ T cells from SCD cases compared to controls. Surface expression of CD4+ T cell CXCR4, CD38 and HLA-DR did not differ between the groups. SCD CD4+ T cells were not less susceptible to HIV infection than controls. Levels of multiple cytokines were elevated in the SCD plasma, but SCD plasma compared to control plasma did not inhibit HIV infection of target cells. In conclusion, our epidemiological data support people with SCD being resistant to HIV infection. Potential mechanisms include lower CD4+ T cell expression of CCR5 and CCR7, balanced by increased CD4 expression and cytokine levels, which did not result in in vitro resistance to HIV infection. Further study is needed to define the risk and pathophysiology of HIV in persons with SCD. |
| Databáze: | OpenAIRE |
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