Accuracy of Endoscopic Diagnosis of Helicobacter pylori Based on the Kyoto Classification of Gastritis: A Multicenter Study
| Autor: | Bin Qin, Jing Zhao, Lei Dong, Shaoxian Xu, Mimi Zhou, Yali Lei, Danyan Chang, Yuan Gao, Baicang Zou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Atrophy Internal medicine unclear atrophy boundary Medicine Kyoto classification of gastritis early gastric cancer Receiver operating characteristic biology RAC reappearance in atrophic mucosa Helicobacter pylori business.industry medicine.disease biology.organism_classification lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Confidence interval Early Gastric Cancer Oncology Multicenter study 030220 oncology & carcinogenesis Diagnostic odds ratio 030211 gastroenterology & hepatology Gastritis medicine.symptom business |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) |
| DOI: | 10.3389/fonc.2020.599218/full |
| Popis: | BackgroundThere is lack of clinical evidence supporting the value of the Kyoto classification of gastritis for the diagnosis of Helicobacter pylori (H. pylori) infection in Chinese patients, and there aren’t enough specific features for the endoscopic diagnosis of past infections, which is of special significance for the prevention of early gastric cancer (GC).MethodsThis was a prospective and multicenter study with 650 Chinese patients. The H. pylori status and gastric mucosal features, including 17 characteristics based on the Kyoto classification and two newly-defined features unclear atrophy boundary (UAB) and RAC reappearance in atrophic mucosa (RAC reappearance) were recorded in a blind fashion. The clinical characteristics of the subjects were analyzed, and the diagnostic odds ratio (DOR), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), area under the receiver operating characteristics curve (ROC/AUC), and 95% confidence intervals were calculated for the different features, individually, and in combination.ResultsFor past infection, the DOR of UAB was 7.69 (95%CI:3.11−19.1), second only to map-like redness (7.78 (95%CI: 3.43−17.7)). RAC reappearance showed the highest ROC/AUC (0.583). In cases in which at least one of these three specific features of past infection was considered positive, the ROC/AUC reached 0.643. For current infection, nodularity showed the highest DOR (11.7 (95%CI: 2.65−51.2)), followed by diffuse redness (10.5 (95%CI: 4.87−22.6)). Mucosal swelling showed the highest ROC/AUC (0.726). Regular arrangement of collecting venules (RAC) was specific for no infection.ConclusionsThis study provides evidence of the clinical accuracy and robustness of the Kyoto classification of gastritis for the diagnosis of H. pylori in Chinese patients, and confirms UAB and RAC reappearance partly supplement it for the diagnosis of past infections, which is of great benefit to the early prevention of GC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|