Pharmacologic Atrial Natriuretic Peptide Reduces Human Leg Capillary Filtration
| Autor: | C. Gunnar Blomqvist, Lynda D. Lane, Alan R. Hargens, Brian G. Firth, S F Vissing, Donald E. Watenpaugh, William Erdman, J. C. Buckey |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Oncotic pressure medicine.medical_specialty Blood Pressure Hematocrit Capillary Permeability Electrocardiography Atrial natriuretic peptide Heart Rate Reference Values Internal medicine Blood plasma medicine Humans Pharmacology Leg medicine.diagnostic_test Chemistry Osmolar Concentration Blood flow Middle Aged Hemoconcentration Plethysmography Blood pressure Endocrinology Circulatory system cardiovascular system Vascular Resistance Cardiology and Cardiovascular Medicine Atrial Natriuretic Factor Blood Flow Velocity hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Journal of Cardiovascular Pharmacology. 26:414-419 |
| ISSN: | 0160-2446 |
| Popis: | Atrial natriuretic peptide (ANP) is produced and secreted by atrial cells. We measured calf capillary filtration rate with prolonged venous-occlusion plethys-mography of supine health male subjects during pharmacologic infusion of ANP (48 pmol/kg/min for 15 min; n equals 6) and during placebo infusion (n equals 7). Results during infusions were compared to prior control measurements. ANP infusion increased plasma (ANP) from 30 plus or minus 4 to 2,568 plus or minus 595 pmol/L. Systemic hemoconcentration occurred during ANP infusion; mean hematocrit and plasma colloid osmotic pressure increased 4.6 and 11.3 percent respectively, relative to pre-infusion baseline values (p is less than 0.05). Mean calf filtration, however was significantly reduced from 0.15 to 0.08 ml/100 ml/min with ANP. Heart rate increased 20 percent with ANP infusion, wheras blood pressure was unchanged. Calf conductance (blood flow/arterial pressure) and venous compliance were unaffected by ANP infusion. Placebo infusion had no effect relative to prior baseline control measurements. Although ANP induced systemic capillary filtration, in the calf, filtration was reduced with ANP. Therefore, phamacologic ANP infusion enhances capillary filtration from the systemic circulation, perhaps at upper body or splanchic sites or both, while having the opposite effect in the leg. |
| Databáze: | OpenAIRE |
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