Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Autor: P. Eline Slagboom, Massimo Mangino, David J. Porteous, Karin Leander, Nancy L. Heard-Costa, Sharon L.R. Kardia, Jennifer Bragg, Ken K. Ong, Igor Rudan, Blair H. Smith, Mark A. Sarzynski, Torben Hansen, James F. Wilson, Weihua Zhang, Zoltán Kutalik, Karl Gertow, Yii-Der Ida Chen, Daniele Cusi, Lu Qi, Nicholas G. Martin, Peter Vollenweider, Thomas W. Winkler, Graciela E. Delgado, Thorkild I. A. Sørensen, André G. Uitterlinden, J. Wouter Jukema, Rajesh Rawal, Dena G. Hernandez, Amy J. Swift, Naveed Sattar, Ruth J. F. Loos, George Dedoussis, Ani Manichaikul, Henrik Vestergaard, Jian'an Luan, Luting Xue, Charles Kooperberg, Rona J. Strawbridge, John-Olov Jansson, Jian Gong, Martina Müller-Nurasyid, L. Adrienne Cupples, Frida Renström, Stephan J. L. Bakker, Ivana Kolcic, Mathias Gorski, Tamara B. Harris, Sandosh Padmanabhan, Stephanie A. Bien, Arthur W. Musk, Cristina Menni, Steve Buyske, Anubha Mahajan, Claudia Schurmann, John Blangero, Natalia Pervjakova, Inês Barroso, Kristin L. Young, Momoko Horikoshi, Robert A. Scott, Ozren Polasek, Shafqat Ahmad, Jeremiah Perez, Stella Trompet, Claude Bouchard, Claudia Langenberg, Paul M. Ridker, Tuomas O. Kilpeläinen, Oddgeir L. Holmen, Tarunveer S. Ahluwalia, Alan F. Wright, Ulf de Faire, Cecilia M. Lindgren, Misa Graff, Jie Huang, Liesbeth Vandenput, Marcel Bruinenberg, Luigi Ferrucci, Johanne Marie Justesen, Audrey Y. Chu, Melanie Waldenberger, Karen L. Mohlke, Ching-Ti Liu, Barbara Thorand, Joseph Hung, Pim van der Harst, Colin A. McKenzie, Sailaja Vedantam, Gitta H. Lubke, Bruna Gigante, Göran Hallmans, Sara Lupoli, Anja Ludolph-Donislawski, Michael Boehnke, Treva Rice, Lori L. Bonnycastle, Daniele Braga, Mika Kähönen, Joel Eriksson, Gonçalo R. Abecasis, Joseph M. Wu, Niels Grarup, Ilja M. Nolte, Jonathan Marchini, Georg Homuth, Pamela A. F. Madden, John Beilby, Andrew D. Johnson, Nanette R. Lee, Caroline Hayward, Unhee Lim, Bamidele O. Tayo, Peter S. Chines, Lynda M. Rose, Amélie Bonnefond, Elena Tremoli, Serena Sanna, David P. Strachan, Barbara McKnight, Narisu Narisu, Anton J. M. de Craen, David R. Weir, Albertine J. Oldehinkel, Jessica Tyrrell, Beverley Balkau, Kirsti Kvaløy, Marie-Claude Vohl, Jennifer A. Smith, Rainer Rauramaa, Andrew C. Heath, Erwin P. Bottinger, Andrew Wong, Günther Silbernagel, Mattias Lorentzon, Philippe Froguel, Uzma Afzal, Tanja B. Grammer, Dabeeru C. Rao, Charlotta Pisinger, Nicola Glorioso, Najaf Amin, Andrew P. Morris, Tanguy Corre, Alan James, Julius S. Ngwa, Jennifer E. Huffman, Gudny Eiriksdottir, Maija Hassinen, Lenore J. Launer, Marit E. Jørgensen, Dorret I. Boomsma, Harry Campbell, Scott Coggeshall, Timothy M. Frayling, Konstantin Strauch, Johanna Kuusisto, David Hadley, Penny Gordon-Larsen, Xuan Deng, Dorothée Thuillier, Albert V. Smith, Jaakko Tuomilehto, Harald Grallert, Lynne J. Hocking, Dan Mellström, M. Carola Zillikens, Lars Lind, Hester M. den Ruijter, Gemma Cadby, Joanne E. Curran, Richard N. Bergman, David J. Stott, Matthias Olden, Veronique Vitart, Robert Luben, Cinzia Sarti, Gert J. de Borst, Lyle J. Palmer, Sven Bergmann, Alexander Teumer, John D. Eicher, Marcus E. Kleber, Marie Loh, Genovefa Kolovou, Iris M. Heid, Gonneke Willemsen, Marie Neergaard Harder, David J. Hunter, Stefania Bandinelli, Francis S. Collins, Hans J. Grabe, Virginia Fisher, John Whitfield, Leo-Pekka Lyytikäinen, Salome Scholtens, Tamuno Alfred, Richard S. Cooper, Jouke-Jan Hottenga, Martina Chittani, Jan A. Staessen, Bernhard K. Krämer, Markku Laakso, Min A. Jhun, Marjo-Riitta Järvelin, Saima Afaq, Rita P. S. Middelberg, Jing Hua Zhao, Toshiko Tanaka, Kent D. Taylor, Rudi G. J. Westendorp, Panagiotis Deloukas, Nina Hutri-Kähönen, Reiner Biffar, Krista Fischer, Leena Kinnunen, Diana Kuh, Jaspal S. Kooner, Caroline S. Fox, Harold Snieder, Pau Navarro, Stéphane Lobbens, Tao Huang, Vilmundur Gudnason, Jacqueline M. Vink, Terrence Forrester, Kari E. North, Annette Peters, Mika Kivimäki, David Schlessinger, Ian Ford, Kristian Hveem, Christopher A. Haiman, Lucia A. Hindorff, Oluf Pedersen, Ingrid B. Borecki, Bruce H. R. Wolffenbuttel, Nicholas J. Wareham, Cornelia M. van Duijn, Lawrence F. Bielak, Loic Le Marchand, Linda S. Adair, Tõnu Esko, Anne U. Jackson, Ying Wu, Eco J. C. de Geus, Jana V. van Vliet-Ostaptchouk, Louis Pérusse, Peter J. van der Most, Ulrike Peters, Magnus Karlsson, Anders Hamsten, Anne E. Justice, Alena Stančáková, Henning Tiemeier, Eric Boerwinkle, Catharina A. Hartman, Claes Ohlsson, Grant W. Montgomery, Elise Lim, Traci M. Bartz, Erik Ingelsson, Martina E. Zimmermann, Laura J. Rasmussen-Torvik, Terho Lehtimäki, Heikki A. Koistinen, Pirjo Komulainen, Damiano Baldassarre, Marten A. Siemelink, Niek Verweij, Gerard Pasterkamp, Markus Juonala, Wei Zhao, Andres Metspalu, Sander W. van der Laan, Tuomo Rankinen, Timo A. Lakka, Yun Ju Sung, Heather M. Stringham, Bruce M. Psaty, Niha Zubair, Stavroula Kanoni, Saskia Haitjema, Bengt Sennblad, Llilda Barata, Morris A. Swertz, Mary F. Feitosa, Tim D. Spector, Paul W. Franks, Qibin Qi, Francesco Cucca, Allan Linneberg, Reija Männikkö, Jonathan Marten, Olli T. Raitakari, Mark I. McCarthy, Joel N. Hirschhorn, Winfried März, Sarah H. Wild, Meena Kumari, Nese Direk, Patricia A. Peyser, Jessica D. Faul, John C. Chambers, Nicholas D. Hastie, Mette Hollensted, Jacek Czajkowski, Daniel I. Chasman, Matthias Nauck, Gérard Waeber, Brendan M. Buckley, Kai Savonen, Judith M. Vonk, Carsten A. Böger, Loic Yengo, Anna Eriksson, Henry Völzke, Pedro Marques-Vidal
Přispěvatelé: Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Groningen Research Institute for Asthma and COPD (GRIAC), Cardiovascular Centre (CVC), Clinicum, Department of Medicine, University of Helsinki, Endokrinologian yksikkö, HUS Internal Medicine and Rehabilitation, Luan, Jian'an [0000-0003-3137-6337], Marten, Jonathan [0000-0001-6916-2014], Langenberg, Claudia [0000-0002-5017-7344], Luben, Robert [0000-0002-5088-6343], Ong, Kenneth [0000-0003-4689-7530], Wareham, Nicholas [0000-0003-1422-2993], Barroso, Ines [0000-0001-5800-4520], Apollo - University of Cambridge Repository, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Biological Psychology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, APH - Personalized Medicine, Epidemiology, Erasmus MC other, Medical Microbiology & Infectious Diseases, Internal Medicine, Child and Adolescent Psychiatry / Psychology, Psychiatry
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Netherlands Twin Register (NTR)
Medicin och hälsovetenskap
Offita
Chemistry(all)
Epidemiology
General Physics and Astronomy
Genome-wide association study
methods [Genome-Wide Association Study]
Biochemistry
Genome-wide association studies
Medical and Health Sciences
Body Mass Index
genetics [Obesity]
Genetics research
IMPUTATION
Body Fat Distribution
genetics [Genetic Predisposition to Disease]
OXIDATIVE STRESS
POPULATION
Adiposity
METABOLIC SYNDROME
Genetics
education.field_of_study
Multidisciplinary
Smoking
Public Health
Global Health
Social Medicine and Epidemiology
genetics [Smoking]
ASSOCIATION
3142 Public health care science
environmental and occupational health
3. Good health
Multidisciplinary Sciences
DEFICIENCY
Phenotype
ADDICTION
Science & Technology - Other Topics
Medical genetics
ddc:500
Waist Circumference
Reykingar
genetics [Adiposity]
Adult
medicine.medical_specialty
Science
Quantitative Trait Loci
Population
genetics [Waist Circumference]
Accounting
Biology
Quantitative trait locus
Physics and Astronomy(all)
Polymorphism
Single Nucleotide
Article
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
SDG 3 - Good Health and Well-being
GWAS
obesity
smoking
MD Multidisciplinary
Genetic predisposition
medicine
Journal Article
Erfðafræði
Humans
Genetic Predisposition to Disease
Obesity
education
Genetic association
Science & Technology
VITAMIN-C
genetics [Quantitative Trait Loci]
Waist-Hip Ratio
business.industry
Biochemistry
Genetics and Molecular Biology(all)
Epistasis
Genetic
Rannsóknir
General Chemistry
ta3121
R1
GENE
Folkhälsovetenskap
global hälsa
socialmedicin och epidemiologi
MICE
030104 developmental biology
3121 General medicine
internal medicine and other clinical medicine
business
Body mass index
Developmental Psychopathology
Imputation (genetics)
Genetics and Molecular Biology(all)
Genome-Wide Association Study
Zdroj: Nature communications, vol. 8, pp. 14977
Nature Communications, 8:14977. Nature Publishing Group
Nature communications 8 (2017). doi:10.1038/ncomms14977
info:cnr-pdr/source/autori:Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltan; Xue, Luting; Mahajan, Anubha; Renstrom, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F.; Bonnefond, Amelie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Harder, Marie Neergaard; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E.; Jackson, Anne U.; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E.; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikainen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P. S.; Mueller-Nurasyid, Martina; Navarro, Pau; Perusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A.; Stancakova, Alena; Strawbridge, Rona J.; Stringham, Heather M.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W.; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Vedantam, Sailaja L.; Verweij, Niek; Vink, Jacqueline M.; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Zhao, Jing Hua; Zimmermann, Martina E.; Zubair, Niha; Abecasis, Goncalo R.; Adair, Linda S.; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J. L.; Bartz, Traci M.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L.; Bottinger, Erwin; Braga, Daniele; Buckley, Brendan M.; Buyske, Steve; Campbell, Harry; Chambers, John C.; Collins, Francis S.; Curran, Joanne E.; de Borst, Gert J.; de Craen, Anton J. M.; de Geus, Eco J. C.; Dedoussis, George; Delgado, Graciela E.; den Ruijter, Hester M.; Eiriksdottir, Gudny; Eriksson, Anna L.; Esko, Tonu; Faul, Jessica D.; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B.; Grarup, Niels; Haitjema, Saskia; Hallmans, Goran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B.; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas D.; Heath, Andrew C.; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J.; Hollensted, Mette; Holmen, Oddgeir L.; Homuth, Georg; Hottenga, Jouke Jan; Huang, Jie; Hung, Joseph; Hutri-Kahonen, Nina; Ingelsson, Erik; James, Alan L.; Jansson, John-Olov; Jarvelin, Marjo-Riitta; Jhun, Min A.; Jorgensen, Marit E.; Juonala, Markus; Kahonen, Mika; Karlsson, Magnus; Koistinen, Heikki A.; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Kramer, Bernhard K.; Kuusisto, Johanna; Kvaloy, Kirsti; Lakka, Timo A.; Langenberg, Claudia; Launer, Lenore J.; Leander, Karin; Lee, Nanette R.; Lind, Lars; Lindgren, Cecilia M.; Linneberg, Allan; Lobbens, Stephane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A. F.; Mannikko, Reija; Marques-Vidal, Pedro; Martin, Nicholas G.; McKenzie, Colin A.; McKnight, Barbara; Mellstrom, Dan; Menni, Cristina; Montgomery, Grant W.; Musk, A. W. (Bill); Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Oldehinkel, Albertine J.; Olden, Matthias; Ong, Ken K.; Padmanabhan, Sandosh; Peyser, Patricia A.; Pisinger, Charlotta; Porteous, David J.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rasmussen-Torvik, Laura J.; Rawal, Rajesh; Rice, Treva; Ridker, Paul M.; Rose, Lynda M.; Bien, Stephanie A.; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A.; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A.; Sennblad, Bengt; Siemelink, Marten A.; Silbernagel, Gunther; Slagboom, P. Eline; Snieder, Harold; Staessen, Jan A.; Stott, David J.; Swertz, Morris A.; Swift, Amy J.; Taylor, Kent D.; Tayo, Bamidele O.; Thorand, Barbara; Thuillier, Dorothee; Tuomilehto, Jaakko; Uitterlinden, Andre G.; Vandenput, Liesbeth; Vohl, Marie-Claude; Volzke, Henry; Vonk, Judith M.; Waeber, Gerard; Waldenberger, Melanie; Westendorp, R. G. J.; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H. R.; Wong, Andrew; Wright, Alan F.; Zhao, Wei; Zillikens, M. Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Boger, Carsten A.; Boomsma, Dorret I.; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I.; Chen, Yii-Der Ida; Chines, Peter S.; Cooper, Richard S.; Cucca, Francesco; Cusi, Daniele; de Faire, Ulf; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans-Jorgen; Gudnason, Vilmundur; Haiman, Christopher A.; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D.; Jukema, Wouter; Kardia, Sharon L. R.; Kivimaki, Mika; Kooner, Jaspal S.; Kuh, Diana; Laakso, Markku; Lehtimaki, Terho; Le Marchand, Loic; Marz, Winfried; McCarthy, Mark I.; Metspalu, Andres; Morris, Andrew P.; Ohlsson, Claes; Palmer, Lyle J.; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M.; Qi, Lu; Rauramaa, Rainer; Smith, Blair H.; Sorensen, Thorkild I. A.; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; Van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J.; Weir, David R.; Whitfield, John B.; Wilson, James F.; Tyrrell, Jessica; Frayling, Timothy M.; Barroso, Ines; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S.; Hirschhorn, Joel N.; Hunter, David J.; Spector, Tim D.; Strachan, David P.; van Duijn, Cornelia M.; Heid, Iris M.; Mohlke, Karen L.; Marchini, Jonathan; Loos, Ruth J. F.; Kilpelainen, Tuomas O.; Liu, Ching-Ti; Borecki, Ingrid B.; North, Kari E.; Cupples, L. Adrienne/titolo:Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits/doi:10.1038%2Fncomms14977/rivista:Nature communications/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, Van Der Laan, S W, Van Der Most, P J, Van Vliet-ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, De Borst, G J, De Craen, A J M, De Geus, E J C, Dedoussis, G, Delgado, G E, Den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D, Hindorff, L, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-kähönen, N, Ingelsson, E, James, A L, Jansson, J, Jarvelin, M, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-vidal, P, Martin, N G, Mckenzie, C A, Mcknight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-torvik, L J, Rawal, R, Rice, T, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-larsen, P, Grabe, H J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, Mccarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, Van Der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, Van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J, Loos, R J F, Kilpeläinen, T O, Liu, C, Borecki, I B, North, K E & Cupples, L A 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8 . https://doi.org/10.1038/ncomms14977
Nature Communications, 8
Nature Communications
Nature Communications [E], 8. Nature Publishing Group
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, Van Der Laan, S W, Van Der Most, P J, Van Vliet-ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, De Borst, G J, De Craen, A J M, De Geus, E J C, Dedoussis, G, Delgado, G E, Den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D, Hindorff, L, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-kähönen, N, Ingelsson, E, James, A L, Jansson, J, Jarvelin, M, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-vidal, P, Martin, N G, Mckenzie, C A, Mcknight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-torvik, L J, Rawal, R, Rice, T, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-larsen, P, Grabe, H J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, Mccarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, Van Der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, Van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J, Loos, R J F, Kilpeläinen, T O, Liu, C, Borecki, I B, North, K E & Cupples, L A 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8, 14977 . https://doi.org/10.1038/ncomms14977
Nature Communications 8(1), 14977 (2017). doi:10.1038/ncomms14977
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K L, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-Costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J C, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg-Gresham, J L, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-Nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S W, van der Most, P J, van Vliet-Ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E P, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, de Borst, G J, De Craen, A J M, de Geus, E J C, Dedoussis, G, Delgado, G E, den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D, Hindorff, L A, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-Kähönen, N, Ingelsson, E, James, A L, Jansson, J-O, Jarvelin, M R, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-Vidal, P, Martin, N G, Mckenzie, C A, McKnight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A B, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-Torvik, L J, Rawal, R, Rice, T K, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M-C, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y-D, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-Larsen, P, Grabe, H J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, McCarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, van der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J L, Loos, R J F, Kilpeläinen, T O, Liu, C-T, Borecki, I B, North, K E & Cupples, L A 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8, 14977 . https://doi.org/10.1038/ncomms14977
Justice, A E, Winkler, T W, Feitosa, M F, Graff, M, Fisher, V A, Young, K L, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, J S, Ahluwalia, T S, Chu, A Y, Heard-Costa, N L, Lim, E, Perez, J, Eicher, J D, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, L F, Bonnefond, A, Bragg-Gresham, J L, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, J E, Jackson, A U, Justesen, J M, Kanoni, S, Kinnunen, L, Kleber, M E, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Marten, J, Middelberg, R P S, Müller-Nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, A V, Smith, J A, Stančáková, A, Strawbridge, R J, Stringham, H M, Sung, Y J, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S W, van der Most, P J, van Vliet-Ostaptchouk, J V, Vedantam, S L, Verweij, N, Vink, J M, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, M E, Zubair, N, Abecasis, G R, Adair, L S, Afaq, S, Afzal, U, Bakker, S J L, Bartz, T M, Beilby, J, Bergman, R N, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Braga, D, Buckley, B M, Buyske, S, Campbell, H, Chambers, J C, Collins, F S, Curran, J E, de Borst, G J, De Craen, A J M, de Geus, E J C, Dedoussis, G, Delgado, G E, den Ruijter, H M, Eiriksdottir, G, Eriksson, A L, Esko, T, Faul, J D, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, T B, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N D, Heath, A C, Hernandez, D G, Hindorff, L, Hocking, L J, Hollensted, M, Holmen, O L, Homuth, G, Huang, J, Hung, J, Hutri-Kähönen, N, Ingelsson, E, James, A L, Jansson, J-O, Jarvelin, M-R, Jhun, M A, Jørgensen, M E, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, H A, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, B K, Kuusisto, J, Kvaløy, K, Lakka, T A, Langenberg, C, Launer, L J, Leander, K, Lee, N R, Lind, L, Lindgren, C M, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, P A F, Männikkö, R, Marques-Vidal, P M, Martin, N G, McKenzie, C A, McKnight, B, Mellström, D, Menni, C, Montgomery, G W, Musk, A B, Narisu, N, Nauck, M, Nolte, I M, Oldehinkel, A J, Olden, M, Ong, K K, Padmanabhan, S, Peyser, P A, Pisinger, C, Porteous, D J, Raitakari, O T, Rankinen, T, Rao, D C, Rasmussen-Torvik, L J, Rawal, R, Rice, T, Ridker, P M, Rose, L M, Bien, S A, Rudan, I, Sanna, S, Sarzynski, M A, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, R A, Sennblad, B, Siemelink, M A, Silbernagel, G, Slagboom, P E, Snieder, H, Staessen, J A, Stott, D J, Swertz, M A, Swift, A J, Taylor, K D, Tayo, B O, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, A G, Vandenput, L, Vohl, M-C, Völzke, H, Vonk, J M, Waeber, G, Waldenberger, M, Westendorp, R G J, Wild, S, Willemsen, G, Wolffenbuttel, B H R, Wong, A, Wright, A F, Zhao, W, Zillikens, M C, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, C A, Boomsma, D I, Bouchard, C, Bruinenberg, M, Chasman, D I, Chen, Y-D, Chines, P S, Cooper, R S, Cucca, F, Cusi, D, Faire, U D, Ferrucci, L, Franks, P W, Froguel, P, Gordon-Larsen, P, Grabe, H-J, Gudnason, V, Haiman, C A, Hayward, C, Hveem, K, Johnson, A D, Wouter Jukema, J, Kardia, S L R, Kivimaki, M, Kooner, J S, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, L L, März, W, McCarthy, M I, Metspalu, A, Morris, A P, Ohlsson, C, Palmer, L J, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, B M, Qi, L, Rauramaa, R, Smith, B H, Sørensen, T I A, Strauch, K, Tiemeier, H, Tremoli, E, van der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, N J, Weir, D R, Whitfield, J B, Wilson, J F, Tyrrell, J, Frayling, T M, Barroso, I, Boehnke, M, Deloukas, P, Fox, C S, Hirschhorn, J N, Hunter, D J, Spector, T D, Strachan, D P, van Duijn, C M, Heid, I M, Mohlke, K L, Marchini, J, Loos, R J F, Kilpeläinen, T O, Liu, C-T, Borecki, I B, North, K E, Cupples, L A & Hottenga, J J 2017, ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ', Nature Communications, vol. 8, 14977, pp. 14977 . https://doi.org/10.1038/ncomms14977
8:14977
Nat. Commun. 8:14977 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
NATURE COMMUNICATIONS
ISSN: 2041-1723
Popis: Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
A full list of acknowledgments appears in the Supplementary Note 4. Co-author A.J.M.d.C. recently passed away while this work was in process. This work was performed under the auspices of the Genetic Investigation of ANthropometric Traits (GIANT) consortium. We acknowledge the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium for encouraging CHARGE studies to participate in this effort and for the contributions of CHARGE members to the analyses conducted for this research. Funding for this study was provided by the Aase and Ejner Danielsens Foundation; Academy of Finland (41071, 77299, 102318, 110413, 117787, 121584, 123885, 124243, 124282, 126925, 129378, 134309, 286284); Accare Center for Child and Adolescent Psychiatry; Action on Hearing Loss (G51); Agence Nationale de la 359 Recherche; Agency for Health Care Policy Research (HS06516); ALF/LUA research grant in Gothenburg; ALFEDIAM; ALK-Abelló A/S; Althingi; American Heart Association (13POST16500011); Amgen; Andrea and Charles Bronfman Philanthropies; Ardix Medical; Arthritis Research UK; Association Diabète Risque Vasculaire; Australian National Health and Medical Research Council (241944, 339462, 389875, 389891, 389892, 389927, 389938, 442915, 442981, 496739, 552485, 552498); Avera Institute; Bayer Diagnostics; Becton Dickinson; BHF (RG/14/5/30893); Boston Obesity Nutrition Research Center (DK46200), Bristol-Myers Squibb; British Heart Foundation (RG/10/12/28456, RG2008/08, RG2008/014, SP/04/002); Medical Research Council of Canada; Canadian Institutes for Health Research (FRCN-CCT-83028); Cancer Research UK; Cardionics; Cavadis B.V., Center for Medical Systems Biology; Center of Excellence in Genomics; CFI; CIHR; City of Kuopio; CNAMTS; Cohortes Santé TGIR; Contrat de Projets État-Région; Croatian Science Foundation (8875); Danish Agency for Science, Technology and Innovation; Danish Council for Independent Research (DFF-1333-00124, DFF-1331-00730B); County Council of Dalarna; Dalarna University; Danish Council for Strategic Research; Danish Diabetes Academy; Danish Medical Research Council; Department of Health, UK; Development Fund from the University of Tartu (SP1GVARENG); Diabetes Hilfs- und Forschungsfonds Deutschland; Diabetes UK; Diabetes Research and Wellness Foundation Fellowship; Donald W. Reynolds Foundation; Dr Robert Pfleger-Stiftung; Dutch Brain Foundation; Dutch Diabetes Research Foundation; Dutch Inter University Cardiology Institute; Dutch Kidney Foundation (E033); Dutch Ministry of Justice; the DynaHEALTH action No. 633595, Economic Structure Enhancing Fund of the Dutch Government; Else Kröner-Fresenius-Stiftung (2012_A147, P48/08//A11/08); Emil Aaltonen Foundation; Erasmus University Medical Center Rotterdam; Erasmus MC and Erasmus University Rotterdam; the Municipality of Rotterdam; Estonian Government (IUT20-60, IUT24-6); Estonian Research Roadmap through the Estonian Ministry of Education and Research (3.2.0304.11-0312); European Research Council (ERC Starting Grant and 323195:SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC); European Regional Development Fund; European Science Foundation (EU/QLRT-2001-01254); European Commission (018947, 018996, 201668, 223004, 230374, 279143, 284167, 305739, BBMRI-LPC-313010, HEALTH-2011.2.4.2-2-EU-MASCARA, HEALTH-2011-278913, HEALTH-2011-294713-EPLORE, HEALTH-F2-2008-201865-GEFOS, HEALTH-F2-2013-601456, HEALTH-F4-2007-201413, HEALTH-F4-2007-201550-HYPERGENES, HEALTH-F7-305507 HOMAGE, IMI/115006, LSHG-CT-2006-018947, LSHG-CT-2006-01947, LSHM-CT-2004-005272, LSHM-CT-2006-037697, LSHM-CT-2007-037273, QLG1-CT-2002-00896, QLG2-CT-2002-01254); Faculty of Biology and Medicine of Lausanne; Federal Ministry of Education and Research (01ZZ0103, 01ZZ0403, 01ZZ9603, 03IS2061A, 03ZIK012); Federal State of Mecklenburg-West Pomerania; Fédération Française de Cardiologie; Finnish Cultural Foundation; Finnish Diabetes Association; Finnish Foundation of Cardiovascular Research; Finnish Heart Association; Fondation Leducq; Food Standards Agency; Foundation for Strategic Research; French Ministry of Research; FRSQ; Genetic Association Information Network (GAIN) of the Foundation for the NIH; German Federal Ministry of Education and Research (BMBF, 01ER1206, 01ER1507); GlaxoSmithKline; Greek General Secretary of Research and Technology; Göteborg Medical Society; Health and Safety Executive; Healthcare NHS Trust; Healthway; Western Australia; Heart Foundation of Northern Sweden; Helmholtz Zentrum München—German Research Center for Environmental Health; Hjartavernd; Ingrid Thurings Foundation; INSERM; InterOmics (PB05 MIUR-CNR); INTERREG IV Oberrhein Program (A28); Interuniversity Cardiology Institute of the Netherlands (ICIN, 09.001); Italian Ministry of Health (ICS110.1/RF97.71); Italian Ministry of Economy and Finance (FaReBio di Qualità); Marianne and Marcus Wallenberg Foundation; the Ministry of Health, Welfare and Sports, the Netherlands; J.D.E. and Catherine T, MacArthur Foundation Research Networks on Successful Midlife Development and Socioeconomic Status and Health; Juho Vainio Foundation; Juvenile Diabetes Research Foundation International; KfH Stiftung Präventivmedizin e.V.; King's College London; Knut and Alice Wallenberg Foundation; Kuopio University Hospital; Kuopio, Tampere and Turku University Hospital Medical Funds (X51001); La Fondation de France; Leenaards Foundation; Lilly; LMUinnovativ; Lundberg Foundation; Magnus Bergvall Foundation; MDEIE; Medical Research Council UK (G0000934, G0601966, G0700931, MC_U106179471, MC_UU_12019/1); MEKOS Laboratories; Merck Santé; Ministry for Health, Welfare and Sports, The Netherlands; Ministry of Cultural Affairs of Mecklenburg-West Pomerania; Ministry of Economic Affairs, The Netherlands; Ministry of Education and Culture of Finland (627;2004-2011); Ministry of Education, Culture and Science, The Netherlands; Ministry of Science, Education and Sport in the Republic of Croatia (108-1080315-0302); MRC centre for Causal Analyses in Translational Epidemiology; MRC Human Genetics Unit; MRC-GlaxoSmithKline pilot programme (G0701863); MSD Stipend Diabetes; National Institute for Health Research; Netherlands Brain Foundation (F2013(1)-28); Netherlands CardioVascular Research Initiative (CVON2011-19); Netherlands Genomics Initiative (050-060-810); Netherlands Heart Foundation (2001 D 032, NHS2010B280); Netherlands Organization for Scientific Research (NWO) and Netherlands Organisation for Health Research and Development (ZonMW) (56-464-14192, 60-60600-97-118, 100-001-004, 261-98-710, 400-05-717, 480-04-004, 480-05-003, 481-08-013, 904-61-090, 904-61-193, 911-11-025, 985-10-002, Addiction-31160008, BBMRI–NL 184.021.007, GB-MaGW 452-04-314, GB-MaGW 452-06-004, GB-MaGW 480-01-006, GB-MaGW 480-07-001, GB-MW 940-38-011, Middelgroot-911-09-032, NBIC/BioAssist/RK 2008.024, Spinozapremie 175.010.2003.005, 175.010.2007.006); Neuroscience Campus Amsterdam; NHS Foundation Trust; National Institutes of Health (1RC2MH089951, 1Z01HG000024, 24152, 263MD9164, 263MD821336, 2R01LM010098, 32100-2, 32122, 32108, 5K99HL130580-02, AA07535, AA10248, AA11998, AA13320, AA13321, AA13326, AA14041, AA17688, AG13196, CA047988, DA12854, DK56350, DK063491, DK078150, DK091718, DK100383, DK078616, ES10126, HG004790, HHSN268200625226C, HHSN268200800007C, HHSN268201200036C, HHSN268201500001I, HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C, HL043851, HL45670, HL080467, HL085144, HL087660, HL054457, HL119443, HL118305, HL071981, HL034594, HL126024, HL130114, KL2TR001109, MH66206, MH081802, N01AG12100, N01HC55015, N01HC55016, N01C55018, N01HC55019, N01HC55020, N01HC55021, N01HC55022, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, N01HC95159, N01HC95160, N01HC95161, N01HC95162, N01HC95163, N01HC95164, N01HC95165, N01HC95166, N01HC95167, N01HC95168, N01HC95169, N01HG65403, N01WH22110, N02HL6‐4278, N01-HC-25195, P01CA33619, R01HD057194, R01HD057194, R01AG023629, R01CA63, R01D004215701A, R01DK075787, R01DK062370, R01DK072193, R01DK075787, R01DK089256, R01HL53353, R01HL59367, R01HL086694, R01HL087641, R01HL087652, R01HL103612, R01HL105756, R01HL117078, R01HL120393, R03 AG046389, R37CA54281, RC2AG036495, RC4AG039029, RPPG040710371, RR20649, TW008288, TW05596, U01AG009740, U01CA98758, U01CA136792, U01DK062418, U01HG004402, U01HG004802, U01HG007376, U01HL080295, UL1RR025005, UL1TR000040, UL1TR000124, UL1TR001079, 2T32HL007055-36, T32GM074905, HG002651, HL084729, N01-HC-25195, UM1CA182913); NIH, National Institute on Aging (Intramural funding, NO1-AG-1-2109); Northern Netherlands Collaboration of Provinces; Novartis Pharma; Novo Nordisk; Novo Nordisk Foundation; Nutricia Research Foundation (2016-T1); ONIVINS; Parnassia Bavo group; Pierre Fabre; Province of Groningen; Päivikki and Sakari Sohlberg Foundation; Påhlssons Foundation; Paavo Nurmi Foundation; Radboud Medical Center Nijmegen; Research Centre for Prevention and Health, the Capital Region of Denmark; the Research Institute for Diseases in the Elderly; Research into Ageing; Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center; Roche; Royal Society; Russian Foundation for Basic Research (NWO-RFBR 047.017.043); Rutgers University Cell and DNA Repository (NIMH U24 MH068457-06); Sanofi-Aventis; Scottish Government Health Directorates, Chief Scientist Office (CZD/16/6); Siemens Healthcare; Social Insurance Institution of Finland (4/26/2010); Social Ministry of the Federal State of Mecklenburg-West Pomerania; Société Francophone du 358 Diabète; State of Bavaria; Stiftelsen för Gamla Tjänarinnor; Stockholm County Council (560183, 592229); Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council; Stroke Association; Swedish Diabetes Association; Swedish Diabetes Foundation (2013-024); Swedish Foundation for Strategic Research; Swedish Heart-Lung Foundation (20120197, 20150711); Swedish Research Council (0593, 8691, 2012-1397, 2012-1727, and 2012-2215); Swedish Society for Medical Research; Swiss Institute of Bioinformatics; Swiss National Science Foundation (3100AO-116323/1, 31003A-143914, 33CSCO-122661, 33CS30-139468, 33CS30-148401, 51RTP0_151019); Tampere Tuberculosis Foundation; Technology Foundation STW (11679); The Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community (G.0880.13, G.0881.13); The Great Wine Estates of the Margaret River Region of Western Australia; Timber Merchant Vilhelm Bangs Foundation; Topcon; Tore Nilsson Foundation; Torsten and Ragnar Söderberg's Foundation; United States – Israel Binational Science Foundation (Grant 2011036), Umeå University; University Hospital of Regensburg; University of Groningen; University Medical Center Groningen; University of Michigan; University of Utrecht; Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) (b2011036); Velux Foundation; VU University’s Institute for Health and Care Research; Västra Götaland Foundation; Wellcome Trust (068545, 076113, 079895, 084723, 088869, WT064890, WT086596, WT098017, WT090532, WT098051, 098381); Wissenschaftsoffensive TMO; Yrjö Jahnsson Foundation; and Åke Wiberg Foundation. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute (NHLBI); the National Institutes of Health (NIH); or the U.S. Department of Health and Human Services.
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