Effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) on clinical global impression in chronic schizophrenia
| Autor: | Johanna Thünker, Gunnar Regenbrecht, Jürgen Brinkmeyer, Joachim Cordes, Wolfgang Wölwer, Thomas Wobrock, Thomas Schneider-Axmann, Marcus W. Agelink, M. Arends, Wolfgang Gaebel, Arian Mobascher, Margarethe Mittrach, Georg Winterer |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Statistics as Topic Global Assessment of Functioning Stimulation Neuropsychological Tests law.invention 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Randomized controlled trial law Outcome Assessment Health Care mental disorders medicine Humans Biological Psychiatry Psychiatric Status Rating Scales Analysis of Variance Middle Aged medicine.disease Transcranial Magnetic Stimulation 030227 psychiatry Clinical trial Transcranial magnetic stimulation Psychiatry and Mental health Schizophrenia Chronic Disease Clinical Global Impression Female Schizophrenic Psychology Analysis of variance Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Psychiatry Research. 177:32-36 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2009.01.014 |
| Popis: | We conducted a randomized, sham-controlled repetitive transcranial magnetic stimulation (rTMS) study in chronic schizophrenia in-patients ( n =35) to evaluate the therapeutic efficacy of 10 Hz stimulation. Patients, who were on stable antipsychotic treatment, were randomly assigned to the active or sham condition. In the active rTMS group, ten sessions with a total of 10,000 stimuli were applied over the left dorsolateral prefrontal cortex at 110% of motor threshold. The sham group received corresponding sham stimulation. Clinical improvement was measured by the Clinical Global Impression scale (primary outcome measure), the Global Assessment of Functioning Scale (GAF) and the Positive and Negative Symptom Scale (PANSS; secondary outcome measures). Between-group comparisons revealed no significant differences in clinical outcome variables. Only a subgroup of patients with pronounced negative symptoms developed some clinical improvement as indicated by significant changes in the GAF-scale. Besides there is some evidence for a more favourable clinical outcome within this subgroup after rTMS in the CGI-S and PANSS negative scale, too. In line with earlier investigations, our results suggest a moderate — potentially clinically relevant — treatment effect of prefrontal 10 Hz rTMS stimulation in chronic patients. However, in our study this beneficial effect was restricted to subjects with pronounced negative symptoms. Clinical trial registration information ClinicalTrial.gov Identifier: NCT00169689, http://www.clinicaltrials.gov. |
| Databáze: | OpenAIRE |
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