International trends in clozapine use: A study in 17 countries
| Autor: | Helga Zoega, Koji Kawakami, Yu-Chiau Shyu, Svetlana Skurtveit, Manuel Enrique Machado-Duque, Leena K. Saastamoinen, Miguel Bernardo, C. Zara Yahni, Takuya Kinoshita, Lise Aagaard, Helle Kieler, Samantha A. Hollingworth, Kari Furu, Catharina C. M. Schuiling-Veninga, Liang-Jen Wang, A. Coma Fusté, Christian Bachmann, Lena Brandt, Kristina Garuoliene, Prasad S. Nishtala, Izumi Sato, David Taylor, S. C. López, Falk Hoffmann, Johan Reutfors, Hélène Verdoux, Dan Siskind, Jorge Enrique Machado-Alba, Luuk J. Kalverdijk, Mufaddal Mahesri, Daniele Piovani, Antonio Clavenna, Krista F. Huybrechts, Marta Cartabia |
|---|---|
| Přispěvatelé: | PharmacoTherapy, -Epidemiology and -Economics |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty pharmacoepidemiology Adolescent International scale Psychological intervention UNITED-STATES Drug Prescriptions 03 medical and health sciences Young Adult 0302 clinical medicine psychotic disorders ADOLESCENTS ANTIPSYCHOTIC MEDICATIONS Medicine Humans Psychiatry Child Clozapine CHILDHOOD-ONSET SCHIZOPHRENIA POPULATION Aged Aged 80 and over PRESCRIPTION PATTERNS clozapine business.industry MORTALITY SECURITY HEALTH SYSTEM Middle Aged Drug Utilization 030227 psychiatry COMMUNITY Psychiatry and Mental health Cross-Sectional Studies CLINICAL-PRACTICE Cohort business 030217 neurology & neurosurgery medicine.drug Demography Antipsychotic Agents |
| Zdroj: | Acta Psychiatrica Scandinavica, 136(1), 37-51. Wiley |
| ISSN: | 2005-2014 0001-690X |
| Popis: | Objective: There is some evidence that clozapine is significantly underutilised. Also, clozapine use is thought to vary by country, but so far no international study has assessed trends in clozapine prescribing. Therefore, this study aimed to assess clozapine use trends on an international scale, using standardised criteria for data analysis.Method: A repeated cross-sectional design was applied to data extracts (2005-2014) from 17 countries worldwide.Results: In 2014, overall clozapine use prevalence was greatest in Finland (189.2/100 000 persons) and in New Zealand (116.3/100 000), and lowest in the Japanese cohort (0.6/100 000), and in the privately insured US cohort (14.0/100 000). From 2005 to 2014, clozapine use increased in almost all studied countries (relative increase: 7.8-197.2%). In most countries, clozapine use was highest in 40-59-year-olds (range: 0.6/100 000 (Japan) to 344.8/100 000 (Finland)). In youths (1019 years), clozapine use was highest in Finland (24.7/100 000) and in the publicly insured US cohort (15.5/100 000).Conclusion: While clozapine use has increased in most studied countries over recent years, clozapine is still underutilised in many countries, with clozapine utilisation patterns differing significantly between countries. Future research should address the implementation of interventions designed to facilitate increased clozapine utilisation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text