Prenatal Multivitamin Use and MTHFR Genotype Are Associated with Newborn Cord Blood DNA Methylation
| Autor: | Rebecca J. Schmidt, Kelly M. Bakulski, M. Daniele Fallin, Katharine Brieger, Craig J. Newschaffer, Jason I. Feinberg, John F. Dou, Irva Hertz-Picciotto, Lisa A. Croen |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Physiology lcsh:Medicine Reproductive health and childbirth Toxicology 0302 clinical medicine Pregnancy Genotype Medicine 2.1 Biological and endogenous factors 030212 general & internal medicine Aetiology skin and connective tissue diseases Child Pediatric 0303 health sciences DNA methylation biology Methylation Vitamins Fetal Blood Cord blood embryonic structures cord blood Female Article 03 medical and health sciences multivitamin Clinical Research Genetics Humans Epigenetics Allele Methylenetetrahydrofolate Reductase (NADPH2) 030304 developmental biology Nutrition business.industry Prevention lcsh:R Human Genome Public Health Environmental and Occupational Health Infant Newborn Infant Perinatal Period - Conditions Originating in Perinatal Period medicine.disease Newborn Good Health and Well Being Methylenetetrahydrofolate reductase MTHFR biology.protein sense organs business |
| Zdroj: | International journal of environmental research and public health, vol 17, iss 24 International Journal of Environmental Research and Public Health, Vol 17, Iss 9190, p 9190 (2020) International Journal of Environmental Research and Public Health Volume 17 Issue 24 |
| Popis: | Background: Fetal development involves cellular differentiation and epigenetic changes&mdash complex processes that are sensitive to environmental factors. Maternal nutrient levels during pregnancy affect development, and methylene tetrahydrofolate reductase (MTHFR) is important for processing the nutrient folate. Hypothesis: We hypothesize that supplement intake before pregnancy and maternal genotype are associated with DNA methylation in newborns. Methods: In the pregnancy cohort, Early Autism Risk Longitudinal Investigation (EARLI), health history, and genotype information was obtained (n = 249 families). Cord blood DNA methylation (n = 130) was measured using the Illumina HumanMethylation450k array and global DNA methylation levels were computed over 455,698 sites. Supplement use preconception and during pregnancy were surveyed at visits during pregnancy. We evaluated associations between maternal preconception supplement intake and global DNA methylation or DNA methylation density distributions of newborn cord blood, stratified by the presence of a variant maternal MTHFR C677T allele. Results: Maternal preconceptional multivitamin intake was associated with cord blood methylation, dependent on maternal MTHFR genotype (interaction term p = 0.013). For mothers without the MTHFR variant allele, multivitamin intake was associated with 0.96% (95% CI: 0.09, 1.83) higher global cord blood methylation (p = 0.04) and was also associated with the cumulative density distribution of methylation (p = 0.03). For mothers with at least one variant allele, multivitamin intake had a null &minus 0.06% (95% CI: &minus 0.45, 0.33) association with global cord blood DNA methylation, and was not associated with the cumulative density distribution (p = 0.37). Conclusions: We observed that cord blood DNA methylation was associated with maternal supplement exposure preconception and maternal genotype. Genetic context should be considered when assessing DNA methylation effects of modifiable risk factors around the time of pregnancy. |
| Databáze: | OpenAIRE |
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