Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins
| Autor: | Geeta M. Kulkarni, N. Premkumar, Chung-Ming Sun, Rajesh G. Kalkhambkar, Chandrappa M. Kamanavalli, Syed Mohammed Basheeruddin Asdaq |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Fluorine-19 NMR
Chemical synthesis Mice chemistry.chemical_compound Coumarins Drug Discovery Animals Organic chemistry heterocyclic compounds Antibacterial agent Inflammation Pharmacology chemistry.chemical_classification Analgesics Aza Compounds Bacteria Bicyclic molecule Organic Chemistry Fungi Fluorine General Medicine Carbon-13 NMR chemistry Drug Design Lactam Proton NMR Lactone |
| Zdroj: | European Journal of Medicinal Chemistry. 43:2178-2188 |
| ISSN: | 0223-5234 |
| Popis: | A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect