Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review
| Autor: | Mohammad Javanbakht, Hassan Abolghasemi, Mandana Kashaki, Hassan Nikoueinejad, Gholam Hossein Alishiri, Ramezan Jafari, Ali Sarafzadeh, Morteza Izadi, Mehrdad Ebrahimi, Nematollah Jonaidi-Jafari, Mosa Asadi, Saeid Fathi, Shi Zhao, Luca Cegolon, Amir Hosein Ghazale, Sina Imanizadeh, Behzad Einollahi |
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| Přispěvatelé: | Izadi, M., Cegolon, L., Javanbakht, M., Sarafzadeh, A., Abolghasemi, H., Alishiri, G., Zhao, S., Einollahi, B., Kashaki, M., Jonaidi-Jafari, N., Asadi, M., Jafari, R., Fathi, S., Nikoueinejad, H., Ebrahimi, M., Imanizadeh, S., Ghazale, A. H. |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ARDS Antioxidant medicine.medical_treatment Immunology Ozone (O3) the Disease Review Lung injury medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Oxidants Photochemical Ozone Immunology and Allergy Medicine pneumonia oxidative stress Humans Pharmacology Lung Photochemical business.industry SARS-CoV-2 COVID-19 ozone (O3) the Pneumonia Oxidants Ozone therapy medicine.disease respiratory tract diseases ALI Oxidative stress 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Oxidative stre business Human |
| Zdroj: | International Immunopharmacology |
| ISSN: | 1878-1705 |
| Popis: | Highlights • COVID-19 activates RAAS which induces oxidative stress leading to cytokine storm. • Ozone therapy can reduce oxidative stress. • Ozone therapy might be an excellent option as a complementary treatment for COVID-19. Severe forms of COVID-19 can evolve into pneumonia, featured by acute respiratory failure due to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In viral diseases, the replication of viruses is seemingly stimulated by an imbalance between pro-oxidant and antioxidant activity as well as by the deprivation of antioxidant mechanisms. In COVID-19 pneumonia, oxidative stress also appears to be highly detrimental to lung tissues. Although, inhaling ozone (O3) gas has been shown to be toxic to the lungs, recent evidence suggests that its administration via appropriate routes and at small doses can paradoxically induce an adaptive reaction capable of decreasing the endogenous oxidative stress. Ozone therapy is recommended to counter the disruptive effects of severe COVID-19 on lung tissues, especially if administered in early stages of the disease, thereby preventing the progression to ARDS. |
| Databáze: | OpenAIRE |
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