Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients
| Autor: | Silvia Jiménez-Morales, Julian Ramírez-Bello, Rosa Elda Barbosa-Cobos, Luis M. Amezcua-Guerra, Jorge Flavio Mendoza-Rincón, Fausto Sánchez-Muñoz, Mónica Sierra-Martínez, Daniel Cadena-Sandoval |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Allergy Genotype Immunology Lupus nephritis Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Gene Frequency immune system diseases Polymorphism (computer science) medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Allele skin and connective tissue diseases Genotyping Mexico Alleles 030203 arthritis & rheumatology business.industry Tumor Necrosis Factor-alpha Odds ratio Middle Aged medicine.disease Lupus Nephritis 030104 developmental biology Haplotypes Rheumatoid arthritis Tumor necrosis factor alpha Female business |
| Zdroj: | Immunologic research. 66(3) |
| ISSN: | 1559-0755 |
| Popis: | The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations. Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population. Our study included 442 patients with SLE and 495 controls. For genotyping, we used the TaqMan 5′ allele discrimination assay. The TNF -238G/A and -1031T/C polymorphisms were associated with SLE susceptibility (odds ratio (OR) 2.1, p = 0.0005 and OR 1.4, p = 0.003, respectively). Gender stratification showed a strong association between TNF -238G/A and SLE in women (OR 2.2, p = 0.00006), while TNF -1031T/C had an OR of 1.5 (p = 0.007). With regard to the TNF -376G/A polymorphism, this also showed association with SLE susceptibility (OR 1.95, p = 0.036) and LN (OR 3.5, p = 0.01). In conclusion, our study provides the first demonstration of association between the TNF -376G/A polymorphism and SLE and LN susceptibility. In addition, our study is the second documenting an association of TNF -1031T/C with SLE susceptibility. We also observed a strong association between TNF -238G/A and SLE susceptibility. The TNF 308G/A polymorphism was not associated with SLE or LN. |
| Databáze: | OpenAIRE |
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