Cascade In Situ Phosphorylation and One-Pot Glycosylation for Rapid Synthesis of Heptose-Containing Oligosaccharides

Autor:	Kwok-Kong Tony Mong, Li-Ching Shen, Yi-Fang Wang, I-Chen Lu, Chia-Wei Pan, Kuang-Chun Cheng
Rok vydání:	2020
Předmět:	inorganic chemicals chemistry.chemical_classification In situ Glycosylation Lipopolysaccharide Organic Chemistry Convergent synthesis Heptose macromolecular substances chemistry.chemical_compound chemistry Biochemistry Phosphorylation Tetrasaccharide Trisaccharide
Zdroj:	The Journal of Organic Chemistry. 85:16060-16071
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c01828
Popis:	We report a one-pot glycosylation strategy for achieving rapid syntheses of heptose (Hep)-containing oligosaccharides. The reported procedure was designed to incorporate an in situ phosphorylation step into an orthogonal one-pot glycosylation. Hep-containing oligosaccharides were assembled directly from building blocks with minimal effort expended on manipulation of protecting and aglycone leaving groups. The utility of our one-pot procedure was illustrated by synthesizing partial core oligosaccharide structure present in the lipopolysaccharide of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdce19b228f369c806317181d78f91f https://doi.org/10.1021/acs.joc.0c01828 Zobrazit plný text záznamu