Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029
| Autor: | Jian Hua Li, Li Mei Wang, Rong Sun, Ke-Qin Zhang, Jin Yan Dong, Kai Ze Shen, Chun Ren Wang, Yu Shu Tang, Le Wang, Yong Ping Zhou, Hong Chuan Song |
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| Rok vydání: | 2008 |
| Předmět: |
Nematoda
Stereochemistry Pharmaceutical Science Bursaphelenchus xylophilus Fresh Water Fungus Heterocyclic Compounds 4 or More Rings Analytical Chemistry Trees Inhibitory Concentration 50 Drug Discovery Botany Animals Pharmacology Ivermectin biology Molecular Structure Chemistry Antinematodal Agents Organic Chemistry Fungi biology.organism_classification Nematode Complementary and alternative medicine Fresh water Molecular Medicine Epoxy Compounds |
| Zdroj: | Journal of natural products. 71(6) |
| ISSN: | 1520-6025 |
| Popis: | Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, preussomerin C (6), preussomerin D (7), (4RS)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (8), and 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (9). The structures of new metabolites were determined by analysis of NMR and MS data and by analogy with the data for the known bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these metabolites displayed weak nematicidal activity against Bursaphelenchus xylophilus, while compound 7 was the most potent. This is the first report of these compounds, which antagonize the Bursaphelenchus xylophilus nematode. |
| Databáze: | OpenAIRE |
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