Of mice and men: hybridoma and recombinant antibodies
| Autor: | M. Little, Gerhard Moldenhauer, S.M Kipriyanov, F. Le Gall |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Genetically modified mouse
medicine.drug_class Transgene Immunology Immunoglobulin Variable Region Immunoglobulins Mice Transgenic Monoclonal antibody Cell Line law.invention Mice Transformation Genetic law medicine Animals Humans Immunoglobulin Fragments Hybridomas Bacteria biology fungi Antibodies Monoclonal food and beverages Plants Genetically Modified Virology Molecular biology Recombinant Proteins Genetically modified organism Milk Cell culture biology.protein Recombinant DNA Antibody Single-Chain Antibodies Biotechnology |
| Zdroj: | Immunology Today. 21:364-370 |
| ISSN: | 0167-5699 |
| DOI: | 10.1016/s0167-5699(00)01668-6 |
| Popis: | Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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