| Autor: |
Uzoamaka Vivian Muoneke, Emmanuel Anayo Onoh, Ekenechukwu Esther Young, Brenda Chidinma Nwatu |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
PAMJ Clinical Medicine, Vol 3, Iss 190 (2020) |
| ISSN: |
2707-2797 |
| DOI: |
10.11604/pamj-cm.2020.3.190.23506 |
| Popis: |
INTRODUCTION: Sickle cell disease is a genetic disorder of haemoglobin characterized by chronic anaemia due to ongoing haemolysis and is frequently associated with recurrent vaso-occlusive crisis (VOC). The affected patients often have impaired immunity and are predisposed to infections. It is known that infections and infestations are important trigger factors towards development of vaso-occlusive crises (VOC) in SCA patients. Aims and objectives: to demonstrate any significant difference in the Haemoglobin levels and frequency of vaso-occlusive crises among children with SCA harbouring intestinal helminthes compared with SCA patients without Intestinal Helminths. METHODS: a hospital based cross sectional study was conducted between August and October 2018 in 120 children aged 2 to 18 years with sickle cell anaemia. Frequency of vaso-occulsive crisis in children with or without intestinal helminths was assessed using a structured questionnaire. Stool and Blood samples were collected and analysed using standard methods. RESULTS: the ages of the children ranged between 2 - 18 yrs, 55.8% were males with a mean age of 8.6(±4.6SD) years. Females had a mean age of 9.1 (±3.9SD) years. Eleven stool samples contained intestinal helminths. The median haemoglobin of the helminth-infected subjects was 6.5g/dl. There was no significant statistical difference in episodes of vaso-occlusive crises in those with or without helminthic infections (p = 0.822) though statistical difference in the haemoglobin levels appeared significant (p-value 0.010). CONCLUSION: haemoglobin levels appeared lower in children with intestinal helminthiasis while the frequency of vaso-occlusive crises did not differ. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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