Rectification of Age-Associated Deficiency in Cytotoxic T Cell Response to Influenza A Virus by Immunization with Immune Complexes
| Autor: | Daniel Wansley, Yongxin Zhang, Biao Zheng, Hongxia He, Innocent N. Mbawuike, Shuhua Han, Kirsten Switzer, Ekaterina Marinova |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Aging
Cellular immunity animal diseases Immunology chemical and pharmacologic phenomena Antigen-Antibody Complex Biology medicine.disease_cause Interferon-gamma Mice Influenza A Virus H1N1 Subtype Immune system Influenza A virus medicine Animals Immunology and Allergy Cytotoxic T cell Cells Cultured Mice Inbred BALB C Cell Differentiation Dendritic Cells Dendritic cell biochemical phenomena metabolism and nutrition Virology Immune complex CTL Hemagglutinins Nucleoproteins Immunization Influenza Vaccines bacteria T-Lymphocytes Cytotoxic |
| Zdroj: | The Journal of Immunology. 179:6153-6159 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.179.9.6153 |
| Popis: | Decline in cellular immunity in aging compromises protection against infectious diseases and leads to the increased susceptibility of the elderly to infection. In particular, Ag-specific cytotoxic T lymphocyte (CTL) response against virus is markedly reduced in an aged immune system. It is of great importance to explore novel strategy in eliciting effective antiviral CTL activity in the elderly. In this study, the efficacy and mechanisms of immunization with immune complexes in overcoming age-associated deficiency in cellular immunity were investigated. In this study, we show that the severely depressed CTL response to influenza A in aged mice can be significantly restored by immunization with immune complexes consisting of influenza A virus and mAb to influenza A nucleoprotein. The main mechanisms underlying this recovery of CTL response induced by immune complex immunization in aged mice are enhanced dendritic cell function and elevated production of IFN-γ in both CD4+ Th1 and CD8+ CTLs. Thus, these results demonstrate that immune complex immunization may represent a novel strategy to elicit effective virus-specific cytotoxic response in an aged immune system, and possibly, to overcome age-related immune deficiency in general. |
| Databáze: | OpenAIRE |
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