Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?
| Autor: | Anibal A. Acosta, Howard W. Jones, Debra L. Jones, Suheil J. Muasher, Richard G. Lester, Vishvanath Karande |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Diethylstilbestrol Uterus Fertilization in Vitro Pregnancy medicine Humans Embryo Implantation Gynecology In vitro fertilisation business.industry Obstetrics Pregnancy Outcome Obstetrics and Gynecology Tubal factor infertility Embryo Transfer medicine.disease Hysterosalpingography Embryo transfer medicine.anatomical_structure Reproductive Medicine Estrogen In utero Prenatal Exposure Delayed Effects Female business medicine.drug |
| Zdroj: | Fertility and Sterility. 54:287-291 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)53705-4 |
| Popis: | Forty-six infertile women with a history of diethylstilbestrol (DES) exposure in utero underwent 149 stimulation attempts for in vitro fertilization (IVF). The mean (+/- SE) number of preovulatory oocytes harvested at retrieval and transferred was 3.9 +/- 3.3 (536/138) and 2.6 +/- 1.4 (328/124). When compared with patients with tubal factor infertility and less than or equal to 4 pre-embryos transferred, the clinical pregnancy rate (15.3% versus 22%) was not statistically different. However, the term/ongoing pregnancy rate was significantly lower in the study group (8% versus 16%). Comparison of the IVF outcome with different uterine anomalies as detected by hysterosalpingogram (n = 29) showed a trend for a worse prognosis in women with constrictions and a combination of T-shape and constrictions. It is concluded that implantation and pregnancy outcome are impaired in DES-exposed women after IVF. |
| Databáze: | OpenAIRE |
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