INTERSPIA: a web application for exploring the dynamics of protein-protein interactions among multiple species
| Autor: | Ju-Yeon Kim, Jaebum Kim, Daehong Kwon, Mikang Sim, Jongin Lee, Daehwan Lee |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computational biology Biology Protein–protein interaction Set (abstract data type) User-Computer Interface 03 medical and health sciences 0302 clinical medicine Protein Interaction Mapping Genetics Web application Databases Protein Internet business.industry Computational Biology Proteins Multiple species Pipeline (software) Visualization 030104 developmental biology Web Server Issue Identification (biology) User interface business Algorithms Software 030217 neurology & neurosurgery |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Proteins perform biological functions through cascading interactions with each other by forming protein complexes. As a result, interactions among proteins, called protein-protein interactions (PPIs) are not completely free from selection constraint during evolution. Therefore, the identification and analysis of PPI changes during evolution can give us new insight into the evolution of functions. Although many algorithms, databases and websites have been developed to help the study of PPIs, most of them are limited to visualize the structure and features of PPIs in a chosen single species with limited functions in the visualization perspective. This leads to difficulties in the identification of different patterns of PPIs in different species and their functional consequences. To resolve these issues, we developed a web application, called INTER-Species Protein Interaction Analysis (INTERSPIA). Given a set of proteins of user's interest, INTERSPIA first discovers additional proteins that are functionally associated with the input proteins and searches for different patterns of PPIs in multiple species through a server-side pipeline, and second visualizes the dynamics of PPIs in multiple species using an easy-to-use web interface. INTERSPIA is freely available at http://bioinfo.konkuk.ac.kr/INTERSPIA/. |
| Databáze: | OpenAIRE |
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