Effects of external counter-pulsation on endothelial function assessed by peripheral artery tonometry, levels of glycaemia and metabolic markers in individuals with type 2 diabetes mellitus
| Autor: | Shih Ling Kao, Maudrene L. S. Tan, Caroline Wei Shan Hoong, Eric Yin Hao Khoo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Manometry Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences Hyperaemia Peripheral Arterial Disease Young Adult 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Counterpulsation Internal Medicine medicine Humans Prospective Studies Endothelial dysfunction education Aged education.field_of_study Singapore medicine.diagnostic_test Neovascularization Pathologic business.industry General Medicine Middle Aged medicine.disease Prognosis Blood pressure Diabetes Mellitus Type 2 Cardiology Female Endothelium Vascular medicine.symptom Lipid profile business Biomarkers Follow-Up Studies |
| Zdroj: | Diabetesmetabolic syndrome. 14(6) |
| ISSN: | 1878-0334 |
| Popis: | Background and aims External counter-pulsation (ECP) generates sheer stress thereby improving endothelial function and anginal symptoms in coronary artery disease. Endothelial dysfunction is also involved in the pathogenesis of T2DM. The aim of this pilot study was to investigate the use of ECP at different doses in improving endothelial function and glycaemic markers in T2DM. Methods This prospective study involved 46 subjects with T2DM randomly assigned to receive 35 sessions of ECP at different regimens (0.5 h versus 1 h) and duration (7 versus 12 weeks). Endothelial function was evaluated by reactive hyperaemia index (RHI) via peripheral arterial tonometry at the start, midpoint and end of study. Other secondary outcomes included fasting glucose, HOMA-IR, HbA1c, blood pressure, lipid profile, weight and vibration sense. Results There was no change in RHI across all 3 regimens of ECP individually or collectively at the end of the study (ΔRHI +0.01%, p = 0.458). Glycaemic markers also remained unchanged at endpoint. Subgroup analysis showed an improvement in RHI (ΔRHI +20.6%, p = 0.0178) in subjects with more severe endothelial dysfunction at baseline. Conclusion ECP did not show a beneficial effect on endothelial function or glycemic control in this South-East Asian population with T2DM at any of the three regimens. This may partly be explained by less severe endothelial dysfunction and less insulin resistance in our population at baseline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect