Validation of a new objective method to assess lipid layer thickness without the need of an interferometer

Autor: Alejandro Cerviño, Cristian Talens-Estarelles, José Vicente García-Marqués, Santiago García-Lázaro
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology
ISSN: 1435-702X
0721-832X
Popis: Purpose This study aimed to develop and validate new metrics to objectively assess the lipid layer thickness (LLT) through the analysis of grey intensity values obtained from the Placido disk pattern reflected onto the tear film. Methods Ocular surface parameters were measured using Oculus Keratograph 5 M in 94 healthy volunteers (43.8 ± 26.8 years). Subjects’ LLT was subjectively classified into 4 groups using an interferometry-based grading scale. New metrics based on the intensity of the Placido disk images were calculated and compared between groups. The repeatability of the new metrics and their diagnostic ability was analysed through receiver operating characteristics (ROC) curves. The level of agreement between the new objective tool and the existing subjective classification scale was analysed by means accuracy, weighted Kappa index and F-measure. Results Mean pixel intensity, median pixel intensity and relative energy at 5.33 s after blinking achieved the highest performance, with a correlation with LLT between r = 0.655 and 0.674 (p F-measure between 0.86 and 0.87. Conclusion The analysis of grey intensity values in videokeratography can be used as an objective tool to assess LLT. These new metrics could be included in a battery of clinical tests as an easy, repeatable, objective and accessible method to improve the detection and monitoring of dry eye disease and meibomian gland dysfunction.
Databáze: OpenAIRE
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