1-Oleoyl Lysophosphatidic Acid: A New Mediator of Emotional Behavior in Rats

Autor: Fernando Rodríguez de Fonseca, Carmen Pedraza, Laura Orio, Guillermo Estivill-Torrús, Leticia Escuredo, Luis J. Santín, A. Bilbao, Francisco Javier Pavón, Estela Castilla-Ortega
Rok vydání: 2014
Předmět:
Male
Psychopharmacology
Emotions
lcsh:Medicine
Anxiety
Biochemistry
Open field
Behavioral Neuroscience
chemistry.chemical_compound
Drug Discovery
Lysophosphatidic acid
Psychology
Periaqueductal Gray
Receptors
Lysophosphatidic Acid
Habituation
lcsh:Science
Receptor
Multidisciplinary
Behavior
Animal
Animal Models
Mental Health
medicine.anatomical_structure
Cytochemistry
Medicine
lipids (amino acids
peptides
and proteins)
biological phenomena
cell phenomena
and immunity
Immunohistochemical Analysis
Proto-Oncogene Proteins c-fos
Immunocytochemistry
Research Article
Drugs and Devices
medicine.medical_specialty
Drug Research and Development
Immunology
Central nervous system
Motor Activity
Model Organisms
Mediator
Internal medicine
Genetics
medicine
Animals
Maze Learning
Biology
Behavior
lcsh:R
Feeding Behavior
Rats
Endocrinology
chemistry
Immunologic Techniques
Rat
lcsh:Q
Gene Function
Lysophospholipids
Neuroscience
Behavioural despair test
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e85348 (2014)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0085348
Popis: The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression.
Databáze: OpenAIRE
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