On the origin of C3 nephritic factor (antibody to the alternative pathway C3 convertase): Evidence for the Adam and Eve concept of autoantibody production
| Autor: | Ann E. Stitzel, George C. Tsokos, Roger E. Spitzer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Immunology Stimulation Germline Pathology and Forensic Medicine Affinity maturation Immunoglobulin Idiotypes Meta-Analysis as Topic Membranoproliferative glomerulonephritis Humans Immunology and Allergy Medicine Autoantibodies Complement C3 Nephritic Factor biology business.industry Infant Newborn Autoantibody medicine.disease C3-convertase Antibodies Anti-Idiotypic Antibody Formation biology.protein Alternative complement pathway Antibody business |
| Zdroj: | Clinical Immunology and Immunopathology. 64:177-183 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(92)90197-v |
| Popis: | The antibody to the alternative pathway C3 convertase, designated C3 nephritic factor or C3NeF, is an autoantibody that is produced in everyone from the time of birth. The elaboration of C3NeF utilizes germline V-region genes which undergo antigen-driven affinity maturation, resulting in an autoantibody that is produced in large amounts with high affinity and narrow specificity. Our data also suggest that under normal conditions, the idiotypic network may play an important part in the control of this autoantibody. Further, a defect in the network with loss of control or inappropriate stimulation may be an underlying mechanism in the unrestricted production of C3NeF in patients with membranoproliferative glomerulonephritis. |
| Databáze: | OpenAIRE |
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