Clinical characteristics and risk factors of cerebral cavernous malformation-related epilepsy

Autor: Peng Zhang, Hui Zhang, Chenjun Shi, Jinyu Zhou, Jun Dong, Minxue Liang, Rong Li, Jing Cheng, Yalan Chen, Jinxian Yuan, Yangmei Chen
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Epilepsy and behavior
ISSN: 1525-5050
Popis: Purpose: This study aimed to summarize the clinical characteristics and explore the risk factors for cerebral cavernous malformation (CCM)-related epilepsy (CRE).Methods: We retrospectively analyzed the clinical data of patients with CCM in our cerebral vascular malformations database. Descriptive statistics were used to present the clinical characteristics of CRE patients. Patients were divided into a CRE and a non-CRE group according to clinical presentation. Binary logistic regression analysis was used to analyze the risk factors of CRE.Results: A total of 199 patients with CCM confirmed by postoperative pathological examination were enrolled, 93 of whom were diagnosed with CRE, and 34 patients had drug-resistant epilepsy. The most common seizure type of CRE patients was focal to bilateral tonic-clonic seizure (FBTCS), followed by focal impaired awareness motor seizure. All CCM lesions were supratentorial, 97.8% of which involved the cerebral cortex, 86.0% of lesions had hemosiderin rim, and 50.5% of lesions were located in the temporal lobe. Binary logistic regression analysis indicated that CCM diagnosis age
Databáze: OpenAIRE