Plasma Alpha-Human Atrial Natriuretic Peptide Concentration in Patients with Acute Lung Injury
| Autor: | Yukio Tsunoda, Keisuke Amaha, Yukio Hirata, Chieko Mitaka, Takashi Nagura, Nobue Sakanishi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Lung Diseases Male Pulmonary and Respiratory Medicine medicine.medical_specialty Diuresis Lung injury Natriuresis Excretion Atrial natriuretic peptide Internal medicine Humans Medicine Alpha-Atrial Natriuretic Peptide Cyclic GMP Aged Aged 80 and over business.industry Respiratory disease Middle Aged medicine.disease Peptide Fragments Endocrinology Acute Disease Circulatory system Female business Atrial Natriuretic Factor |
| Zdroj: | American Review of Respiratory Disease. 146:43-46 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/ajrccm/146.1.43 |
| Popis: | To elucidate the pathophysiologic role of alpha-human atrial natriuretic peptide (alpha-hANP) in acute lung injury, plasma alpha-hANP concentrations were measured in 15 patients with severe lung injury, and the relationships of plasma alpha-hANP levels to the severity of lung injury, diuresis/natriuresis, and fluid balance were examined. The mean concentrations of plasma alpha-hANP (188.0 +/- 94.6 pg/ml) in patients with severe lung injury at the entry into the study were significantly (p less than 0.001) higher than those in normal subjects (31.7 +/- 12.0 pg/ml). Plasma alpha-hANP levels decreased in parallel with the improvement of lung injury in nine of 15 patients, whereas they changed little, if any, in the patients who did not recover. Plasma alpha-hANP concentrations correlated positively with urine volume, urinary sodium excretion, and excreted fraction of filtered sodium, but they correlated negatively with fluid balance at the onset of the disease as well as during the clinical course. It is suggested that elevation of circulatory alpha-hANP may reflect an adaptative mechanism to remove excessive fluid retention and reduce pulmonary hypertension for acute lung injury. |
| Databáze: | OpenAIRE |
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