HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism
| Autor: | Nicole C. Riddle, Benjamin B. Mills, Andrew D. Thomas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Life Cycles Euchromatin DNA Repair Chromosomal Proteins Non-Histone lcsh:Medicine Gene Expression medicine.disease_cause Biochemistry 0302 clinical medicine Larvae Heterochromatin Gene expression Medicine and Health Sciences Drosophila Proteins lcsh:Science Protein Metabolism Genetics Regulation of gene expression Mutation 0303 health sciences Multidisciplinary Chromosome Biology Drosophila Melanogaster Reproduction Eukaryota Nuclear Proteins Animal Models Chromatin Insects Experimental Organism Systems Adipose Tissue embryonic structures Drosophila Epigenetics Female Anatomy Research Article endocrine system animal structures Arthropoda DNA repair Citric Acid Cycle Longevity Biology Research and Analysis Methods 03 medical and health sciences Model Organisms medicine Animals Gene Alleles 030304 developmental biology Gene Expression Profiling lcsh:R Organisms Biology and Life Sciences Cell Biology Feeding Behavior Invertebrates Oxidative Stress 030104 developmental biology Biological Tissue Metabolism Fertility Gene Expression Regulation Animal Studies lcsh:Q Heterochromatin protein 1 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 10, p e0205867 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Heterochromatin Protein 1 (HP1) proteins are an important family of chromosomal proteins conserved among all major eukaryotic lineages. While HP1 proteins are best known for their role in heterochromatin, many HP1 proteins function in euchromatin as well. As a group, HP1 proteins carry out diverse functions, playing roles in the regulation of gene expression, genome stability, chromatin structure, and DNA repair. While the heterochromatic HP1 proteins are well studied, our knowledge of HP1 proteins with euchromatic distribution is lagging behind. We have created the first mutations in HP1B, a Drosophila HP1 protein with euchromatic function, and the Drosophila homolog most closely related to mammalian HP1α, HP1β, and HP1γ. We find that HP1B is a non-essential protein in Drosophila, with mutations affecting fertility and animal activity levels. In addition, animals lacking HP1B show altered food intake and higher body fat levels. Gene expression analysis of animals lacking HP1B demonstrates that genes with functions in various metabolic processes are affected primarily by HP1B loss. Our findings suggest that there is a link between the chromatin protein HP1B and the regulation of metabolism. |
| Databáze: | OpenAIRE |
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