Seasonal expressions of growth hormone receptor, insulin-like growth factor 1 and insulin-like growth factor 1 receptor in the scented glands of the muskrats (Ondatra zibethicus)
| Autor: | Qiang Weng, Haolin Zhang, Yuanyuan Guo, Chunjiao Zhang, Zhengrong Yuan, Wenqian Xie, Yingying Han, Zeqi Tang |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030209 endocrinology & metabolism Growth hormone receptor Biology Receptor IGF Type 1 03 medical and health sciences Insulin-like growth factor Paracrine signalling 0302 clinical medicine Endocrinology Internal medicine medicine Endocrine system Animals Scent Glands Insulin-Like Growth Factor I Receptor Autocrine signalling 030304 developmental biology 0303 health sciences Cell growth Arvicolinae Growth factor Receptors Somatomedin Receptors Somatotropin MicroRNAs Ki-67 Antigen Gene Expression Regulation Growth Hormone Animal Science and Zoology Seasons hormones hormone substitutes and hormone antagonists |
| Zdroj: | General and comparative endocrinology. 281 |
| ISSN: | 1095-6840 |
| Popis: | The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) system plays an important role in regulating the cellular growth and organ development. The present study investigated the seasonal expressions of growth hormone receptor (GHR), IGF-1 and insulin-like growth factor 1 receptor (IGF-1R) in the scented glands of the muskrats. Morphological changes in the scented glands of the muskrats were observed significantly between the breeding and non-breeding seasons. Immunohistochemically, the expressions of GH, GHR, IGF-1 and IGF-1R were found in glandular cells and epithelial cells of the scented glands in both seasons. The protein and mRNA expression levels of GHR, IGF-1 and IGF-1R in the scented glands during the breeding season were noticeably higher than those of the non-breeding season. In parallel, the levels of GH and IGF-1 in the sera and scented glands were remarkably higher during the breeding season. In addition, small RNA sequencing showed that the predicted targets of the significantly changed hsa-miR-5100 and mmu-miR-6937-5p might regulate the expressions of Ghr, Igf-1 or Igf-1r. These results suggested that the morphological changes in the scented glands of the muskrats during the different seasons might be related to the expression levels of GHR, IGF-1 and IGF-1R. Meanwhile, GHR/IGF-1 system might regulate the scented glandular functions via endocrine or autocrine/paracrine manners. |
| Databáze: | OpenAIRE |
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