Impact of Acid Suppression Therapy on Iron Supplementation in the Pediatric Intensive Care Unit
| Autor: | Shirley Fan, K Ashley Jones, Sheryl Falkos, Emily Hailstone, Allison M. Chung, Rosa Vidal, Philippe Gaillard |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Anemia medicine.medical_treatment Proton-pump inhibitor 030204 cardiovascular system & hematology Hematocrit Gastroenterology Ferrous Ranitidine 03 medical and health sciences 0302 clinical medicine Antacid hemic and lymphatic diseases Internal medicine Medicine Pharmacology (medical) medicine.diagnostic_test business.industry Research medicine.disease Pediatrics Perinatology and Child Health Serum iron 030211 gastroenterology & hepatology Hemoglobin business medicine.drug |
| Zdroj: | J Pediatr Pharmacol Ther |
| ISSN: | 1551-6776 |
| Popis: | OBJECTIVE We assessed the impact of acid suppression therapy (i.e., ranitidine or proton pump inhibitors) on iron supplementation and its ability to maintain or alter laboratory values that are commonly associated with anemia. METHODS This was a prospective, observational trial. The primary outcome was changes in serum iron levels from baseline. Secondary outcomes were changes in hemoglobin (Hgb) and hematocrit (Hct), transfusions, and maintenance of an alkalotic gastric pH. RESULTS Thirty-four patients (mean 24 ± 43 months) met inclusion criteria. The serum iron levels increased to 50.9 ± 24.6 mcg/dL by day 3. The mean difference from baseline was 1.5 mcg/dL (95% CI, 1.14–1.98, p = 0.0056). Gastric pH increased to 4.68 ± 1.49 on day 5. The mean Hgb and Hct increased on day 5 to 10 ± 1.06 g/dL and 29.6% ± 3.27%, respectively. The mean difference of Hgb was 1.15 g/dL (95% CI, 0.51–1.78, p = 0.0009). The mean difference of Hct was 3.04% (95% CI, 1.11–4.97, p = 0.0032). CONCLUSIONS The use of antacids along with oral ferrous sulfate supplementation did not affect the absorption of iron. Serum iron, Hgb, and Hct all showed statistically significant increases despite combined antacid and iron therapy. Thus, despite use of antacids, combination use showed increases in iron absorption. |
| Databáze: | OpenAIRE |
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