Drug-metal interactions: copper(II) complex of the antidiabetic drug acetohexamide and pyridine
| Autor: | Abbas Pezeshk, Vida Pezeshk |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Models
Molecular Stereochemistry Pyridines Electron Spin Resonance Spectroscopy chemistry.chemical_element Crystal structure Biochemistry Copper Inorganic Chemistry chemistry.chemical_compound Crystallography chemistry Unpaired electron Acetohexamide X-Ray Diffraction Pyridine X-ray crystallography medicine Molecule Monoclinic crystal system medicine.drug |
| Zdroj: | Journal of inorganic biochemistry. 38(3) |
| ISSN: | 0162-0134 |
| Popis: | The preparation, spectral properties, and crystal structure of a copper(II) complex of 4-acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide, which is known as acetohexamide, and pyridine are reported. The complex Cu(AH)2(py)2, where AH = acetohexamide and py = pyridine, was prepared and characterized by X-ray and ESR. The complex is monoclinic, space group P2(1)/a, with a = 17.412(6), b = 9.039(2), c = 26.531(10) A, beta = 102.24(2) degrees, and Z = 4. The final refinement used 3892 unique reflections and gave an R value of 0.0646. The copper atom is surrounded by four nitrogen atoms in a square-planar arrangement, two from the acetohexamide ligands (Cu-N = 2.009 A) and two from the pyridine molecules (Cu-N = 2.016 A) in a trans geometry. The ESR data support a similar coordination behavior of the copper (g parallel greater than g perpendicular greater than ge) with the unpaired electron in the dx2-y2 orbital. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|