Anti-Osteoporotic Activity of Pueraria lobata Fermented with Lactobacillus paracasei JS1 by Regulation of Osteoblast Differentiation and Protection against Bone Loss in Ovariectomized Mice
| Autor: | Se Chan Kang, Yeong-Geun Lee, Seon Yu Kim, Jeong Eun Kwon, Taehyun Kim, Hee-Ju Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pueraria Bone disease Fermentation industries. Beverages. Alcohol Osteoporosis Plant Science Biochemistry Genetics and Molecular Biology (miscellaneous) Bone resorption Bone remodeling Internal medicine medicine fermentation Bone mineral TP500-660 biology Chemistry Osteoblast medicine.disease biology.organism_classification ovariectomized-induced model medicine.anatomical_structure Endocrinology Pueraria lobata Ovariectomized rat osteoblast Lactobacillus Food Science |
| Zdroj: | Fermentation, Vol 7, Iss 186, p 186 (2021) Fermentation Volume 7 Issue 3 |
| ISSN: | 2311-5637 |
| Popis: | Osteoporosis is the most common bone disease associated with low bone mineral density. It is the process of bone loss and is most commonly caused by decreased estrogen production in women, particularly after menopause. Pueraria lobata, which contains various metabolites, especially isoflavone, is widely known as regulator for bone mineral contents. In this study, the effects of the P. lobata extract (PE) with or without fermentation with Lactobacillus paracasei JS1 (FPE) on osteoporosis were investigated in vitro and in vivo. The effects of PE and FPE on human osteoblastic MG63 cells, RAW 264.7 cells, and ovariectomized (OVX)-induced model mice were analyzed at various ratios. We found that FPE increased calcium deposition and inhibited bone resorption by in vitro assay. Furthermore, treatment with PE and FPE has significantly restored destroyed trabecular bone in the OVX-induced bone loss mouse model. Overall, FPE demonstrated bioactivity to prevent bone loss by decreasing bone turnover. |
| Databáze: | OpenAIRE |
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