Implementation of cancer next-generation sequencing testing in a community hospital
| Autor: | Jennifer Westfall, Stacie Lupo, Tamara Smith, Yassmine Akkari |
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| Rok vydání: | 2019 |
| Předmět: |
Modalities
Computer science business.industry Computational Biology High-Throughput Nucleotide Sequencing Hospitals Community Genomics Sequence Analysis DNA General Medicine Medical Oncology Precision medicine Data science Community hospital Identification (information) Workflow Neoplasms Paradigm shift Mutation Commentary Humans Personalized medicine Precision Medicine business |
| Zdroj: | Cold Spring Harbor Molecular Case Studies |
| ISSN: | 2373-2873 2373-2865 |
| Popis: | In the current era of personalized medicine, the field of oncology is witnessing a paradigm shift in patient care that is driving a tighter integration of genomic analysis modalities in patient care decision. This is driven by the expanding category of targeted therapies that require a broader understanding of the mutational profile of patient samples to more precisely guided personalized treatment decisions. Next-generation sequencing (NGS) has proved to be of tremendous power in detecting and characterizing a broad spectrum of activating or loss-of-function mutations across many gene targets. This power of NGS also results in significant challenges related to technical expertise, bioinformatics, computing infrastructure, laboratory practices, and integration into clinical decision-making. These challenges are particularly relevant to smaller and mid-tier hospital networks that are faced with the need to modernize their clinical practices and offer their patients access to advanced genomic technologies to improve outcomes. Adoption of such personalized medicine relies on information about a patient's cancer genome and the identification of its variants. This is best achieved using NGS. However, there are challenges to the adoption of such a complex technology and workflow, especially in smaller hospital systems. This commentary summarizes key considerations and challenges related to implementation of NGS in a community hospital setting. |
| Databáze: | OpenAIRE |
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