Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men
| Autor: | Ayako Suzuki, Joel E. Lavine, Norah A. Terrault, Katherine P. Yates, Monika Sarkar, Toni E. Ziegler, Sandeep Dhindsa, Ryan M. Gill |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Chronic liver disease digestive system Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Fibrosis Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Humans Testosterone Obesity Hepatology business.industry nutritional and metabolic diseases Testosterone (patch) medicine.disease digestive system diseases Clinical research Liver 030220 oncology & carcinogenesis Cohort 030211 gastroenterology & hepatology business |
| Zdroj: | Clin Gastroenterol Hepatol |
| ISSN: | 1542-3565 |
| Popis: | With rising prevalence of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease. One-third of obese or diabetic men have subnormal free and bioavailable testosterone concentrations.1 Several studies have further shown low testosterone to be associated with imaging-confirmed NAFLD in men,2 although it is unknown whether low testosterone confers increased risk of more clinically relevant manifestations of NAFLD, including nonalcoholic steatohepatitis (NASH) and NASH fibrosis. We therefore aimed to evaluate the association of testosterone with histologic features of NAFLD among a representative cohort of men from the multicenter NASH Clinical Research Network (NASH CRN). |
| Databáze: | OpenAIRE |
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