Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder
| Autor: | Susan W. Harris, Nicole Tartaglia, Catalina García-Nonell, Eugenia Rigau Ratera, Michele Y. Ono, Flora Tassone, David R Hessl, Emily Marvin, Randi J Hagerman |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Adolescent Neurological disorder behavioral disciplines and activities Article Epilepsy Trinucleotide Repeats Seizures mental disorders Genetics medicine Pervasive developmental disorder Humans Medical history Autistic Disorder Child Genetics (clinical) Retrospective Studies Chromosome Aberrations Mosaicism business.industry medicine.disease Developmental disorder Fragile X syndrome Child Development Disorders Pervasive Autism spectrum disorder Child Preschool Fragile X Syndrome Autism business |
| Zdroj: | American Journal of Medical Genetics Part A. :1911-1916 |
| ISSN: | 1552-4833 1552-4825 |
| DOI: | 10.1002/ajmg.a.32290 |
| Popis: | This study examined whether secondary medical diagnoses that affect CNS function (i.e., seizures, malformations, or genetic disorders), are more likely to occur in individuals with fragile X syndrome (FXS) and autism spectrum disorder (FXS + ASD) or FXS alone. Ninety males (3-25 years) with FXS or FXS + ASD were evaluated for secondary medical diagnoses by medical history and examination. A significant difference in the incidence of medical problems was found between patients with FXS + ASD (38.6%) and FXS alone (18.2%, P0.05). Medical problems that affect the CNS are more likely to occur in those with FXS + ASD and it is probable that additional brain dysfunction associated with these medical problems enhance the risk of autism in those with FXS. |
| Databáze: | OpenAIRE |
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