Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands

Autor:	Hidenori Takahashi, Younes Bekkali, Alison J. Capolino, Thomas Gilmore, Susan E. Goldrick, Richard M. Nelson, Donna Terenzio, Ji Wang, Ljiljana Zuvela-Jelaska, John Proudfoot, Gerald Nabozny, David Thomson
Rok vydání:	2006
Předmět:	Models Molecular Transcriptional Activation Transcription Genetic Clinical Biochemistry Anti-Inflammatory Agents Pharmaceutical Science Ligands Biochemistry Dexamethasone Structure-Activity Relationship Receptors Glucocorticoid Drug Discovery Humans Promoter Regions Genetic Molecular Biology Molecular Structure Interleukin-6 Organic Chemistry Receptors Mineralocorticoid Mammary Tumor Virus Mouse Receptors Estrogen Quinolines Molecular Medicine Receptors Progesterone HeLa Cells Interleukin-1
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 16:1549-1552
ISSN:	0960-894X
Popis:	We report the discovery of a novel class of glucocorticoid receptor (GR) ligands based on 1,2-dihydroquinoline molecular scaffold. The compounds exhibit good GR binding affinity and selectivity profile against other nuclear hormone receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbdc57440c4c342f5801e2dff50dff5 https://doi.org/10.1016/j.bmcl.2005.12.043 Zobrazit plný text záznamu Full Text from ScienceDirect