Locoregional relapse is a strong prognostic indicator of distant metastatic progression in breast cancer patients after negative sentinel lymph node biopsy
| Autor: | Michał Falco, Andrzej Kram, Bartłomiej Masojć |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Axillary lymph nodes medicine.diagnostic_test business.industry medicine.medical_treatment Sentinel lymph node medicine.disease 030218 nuclear medicine & medical imaging Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Biopsy Internal Medicine medicine Surgery Lymph Radiology Risk factor business Mastectomy |
| Zdroj: | The Breast Journal. 26:2364-2370 |
| ISSN: | 1524-4741 1075-122X |
| DOI: | 10.1111/tbj.14118 |
| Popis: | PURPOSE Sentinel lymph node biopsy is routinely used in breast cancer patients with clinically negative axillary lymph nodes. Locoregional relapses after negative sentinel lymph node biopsy are infrequent, occurring in up to 3% of patients. METHODS Six thousand and eight patients underwent breast cancer surgery in our center between 2006 and 2015. We analyzed 1466 patients with negative sentinel lymph node biopsy and no prior systemic treatment. Mastectomy without irradiation was used in 25.4% of these patients and breast-conserving surgery with adjuvant radiotherapy in 74.6%. Forty-seven (3.21%) locoregional relapses were identified within a median of 51 months (10-138 months). The molecular type was analyzed as a risk factor for locoregional relapses and distant metastases. The locoregional relapse location was then analyzed as a risk factor for distant metastases. RESULTS Triple-negative breast cancer (P = .003), age |
| Databáze: | OpenAIRE |
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