Dose and Exposure Time-Dependent Renal and Hepatic Effects of Intraperitoneally Administered Fumonisin B1 in Rats
| Autor: | Melinda Kovács, R. Glávits, Miklós Mézes, Mariam Kachlek, Judit Szabó-Fodor, Krisztián Balogh, András Szabó, Omeralfaroug Ali, Yarsmin Yunus Zeebone |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty hepatotoxicity Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment lcsh:Medicine Toxicology medicine.disease_cause Nephrotoxicity Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Internal medicine medicine rat dose-dependence Fumonisin B1 Kidney Creatinine nephrotoxicity lcsh:R genotoxicity food and beverages 04 agricultural and veterinary sciences Glutathione 040401 food science 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry fumonisin B1 Oxidative stress |
| Zdroj: | Toxins Volume 10 Issue 11 Toxins, Vol 10, Iss 11, p 465 (2018) |
| ISSN: | 2072-6651 |
| DOI: | 10.3390/toxins10110465 |
| Popis: | Male Wistar rats were treated intraperitoneally (i.p.) with fumonisin B1 (FB1 0, 20, 50 and 100 mg/kg dietary dose equivalent) for 5 and 10 days (n = 24&ndash 24 in each setting) to gain dose- and time-dependent effects on antioxidant status and oxidative stress response, clinical chemical endpoints and liver, kidney and lung histopathology and lymphocyte damage (genotoxicity). FB1 decreased feed intake, body weight gain and absolute liver weight, irrespective of the toxin dose. Relative kidney weight increased in the 10-day setting. Linear dose response was found for plasma aspartate aminotransferase, alanine aminotransferase, total cholesterol, urea and creatinine, and exposure time-dependence for plasma creatinine level. The latter was coupled with renal histopathological findings, tubular degeneration and necrosis and the detachment of tubular epithelial cells. The pronounced antioxidant response (reduced glutathione accretion, increasing glutathione peroxidase activity) referred to renal cortical response (5&ndash 10 days exposure at 50&ndash 100 ppm FB1). Hepatic alterations were moderate, referring to initial phase lipid peroxidation (exposure time dependent difference of conjugated diene and triene concentrations), and slight functional disturbance (&uarr total cholesterol). Lymphocyte DNA damage was moderate, supporting a mild genotoxic effect of FB1. |
| Databáze: | OpenAIRE |
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