Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling
| Autor: | Ge Zhang, Joseph Lee, Cory Swingen, Xiaohong Wang, Jianyi Zhang, Catherine M. Verfaillie, Qingsong Hu, Abdul Mansoor, Sherry Boozer, Robert J. Bache, Lepeng Zeng, Piradeep Suntharalingam, Abner M. Mhashilkar, Arthur H. L. From, Julia Feygin, Robert J. Deans, Carmelo J. Panetta |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Phosphocreatine Swine Sus scrofa Myocardial Infarction Neovascularization Physiologic chemistry.chemical_compound Random Allocation Adenosine Triphosphate Physiology (medical) Internal medicine medicine Animals Regeneration Cell Lineage Myocytes Cardiac Myocardial infarction Artery occlusion Progenitor cell Ventricular remodeling Ejection fraction Ventricular Remodeling business.industry Multipotent Stem Cells Myocardium Cell Differentiation medicine.disease Magnetic Resonance Imaging Myocardial Contraction Transplantation chemistry Heart failure Models Animal Cardiology Cyclosporine Female Cardiology and Cardiovascular Medicine business Energy Metabolism Immunosuppressive Agents |
| Zdroj: | Circulation. 115(14) |
| ISSN: | 1524-4539 |
| Popis: | Background— The present study examined whether transplantation of adherent bone marrow–derived stem cells, termed pMultistem, induces neovascularization and cardiomyocyte regeneration that stabilizes bioenergetic and contractile function in the infarct zone and border zone (BZ) after coronary artery occlusion. Methods and Results— Permanent left anterior descending artery occlusion in swine caused left ventricular remodeling with a decrease of ejection fraction from 55±5.6% to 30±5.4% (magnetic resonance imaging). Four weeks after left anterior descending artery occlusion, BZ myocardium demonstrated profound bioenergetic abnormalities, with a marked decrease in subendocardial phosphocreatine/ATP ( 31 P magnetic resonance spectroscopy; 1.06±0.30 in infarcted hearts [n=9] versus 1.90±0.15 in normal hearts [n=8; P P P P P Conclusions— Thus, allogeneic pMultistem improved BZ energetics, regional contractile performance, and global left ventricular ejection fraction. These improvements may have resulted from paracrine effects that include increased vascular density in the BZ and spared myocytes in the infarct zone. |
| Databáze: | OpenAIRE |
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