Psychotropic Medication After Intensive Care Unit–Treated Pediatric Traumatic Brain Injury

Autor: Tero Ala-Kokko, Atte Karppinen, Stepani Bendel, Ruut Laitio, Matti Reinikainen, Rahul Raj, Era D. Mikkonen, Sanna Hoppu, Markus B. Skrifvars
Přispěvatelé: Anestesiologian yksikkö, HUS Perioperative, Intensive Care and Pain Medicine, Helsinki University Hospital Area, University of Helsinki, HUS Emergency Medicine and Services, Department of Diagnostics and Therapeutics, HUS Neurocenter, Neurokirurgian yksikkö, Staff Services
Rok vydání: 2020
Předmět:
Male
medicine.medical_treatment
CHILDREN
Logistic regression
3124 Neurology and psychiatry
law.invention
Traumatic brain injury
0302 clinical medicine
3123 Gynaecology and paediatrics
law
Brain Injuries
Traumatic
Health care
Child
Finland
Intensive care units
PSYCHIATRIC-DISORDERS
Intensive care unit
3. Good health
Neurology
Child
Preschool
Cohort
Female
Psychoactive agents
medicine.medical_specialty
Adolescent
MODELS
Drug Prescriptions
03 medical and health sciences
Population at risk
Developmental Neuroscience
030225 pediatrics
Intensive care
medicine
Humans
COHORT
Antipsychotic
ADOLESCENT PSYCHOPHARMACOLOGY
Retrospective Studies
Psychotropic Drugs
business.industry
3112 Neurosciences
medicine.disease
TRENDS
Stimulant
Pediatrics
Perinatology and Child Health
Emergency medicine
Neurology (clinical)
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Pediatric Neurology. 112:64-70
ISSN: 0887-8994
DOI: 10.1016/j.pediatrneurol.2020.05.002
Popis: Background: Our aim was to assess the occurrence and risk factors for psychotropic medication use after pediatric traumatic brain injury treated in the intensive care unit. Methods: We combined data from the Finnish Intensive Care Consortium database, data on reimbursed medications from the Social Insurance Institute, and individual electronic health care data. We analyzed data on children aged five to 17 years treated for traumatic brain injury in intensive care units of four university hospitals in Finland during 2003 to 2013 and being alive six months after injury with no history of psychotropic medication use before traumatic brain injury. Results: We identified 248 patients of whom 46 (19%) were prescribed a new psychotropic medication after traumatic brain injury. In multivariable logistic regression, a higher age associated with a higher probability for use of any psychotropic medication. Subgroup analyses showed that higher age associated with an increased risk of antidepressant and antipsychotic use but with a decreased risk of stimulant use. Apart from age, we found no other clinical, radiological, or treatment-related factors that significantly associated with subsequent use of psychotropics. Psychotropic medication was most common (45%) in children aged 12 to 17 years and had moderate disability at six-month follow-up. Conclusions: One fifth of children treated in the intensive care unit for traumatic brain injury were prescribed a new psychotropic medication during a median follow-up of three years and five months. Psychotropic medication was most common among teenagers with moderate post-traumatic disability. The need and use of psychotropics postinjury seem multifactorial and not related to any traumatic brain injury type. (C) 2020 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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