Impact of acute sleep deprivation on dynamic functional connectivity states
| Autor: | David Elmenhorst, D. Lange, Eva-Maria Elmenhorst, Daniel Aeschbach, Changhong Li, Andreas Bauer, Judith Fronczek-Poncelet, Tina Kroll, Andreas Matusch, E. Hennecke |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Audiology Schlaf und Humanfaktoren 050105 experimental psychology Arousal 03 medical and health sciences Young Adult 0302 clinical medicine test–retest reliability medicine Connectome Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging ddc:610 Research Articles Dynamic functional connectivity acute sleep deprivation light sleep/drowsiness Radiological and Ultrasound Technology Resting state fMRI resting‐state fMRI business.industry dynamic connectivity states 05 social sciences Neuropsychology Brain Sleep in non-human animals Actigraphy Magnetic Resonance Imaging Dwell time Sleep deprivation Neurology Sleep Deprivation Wakefulness Female Neurology (clinical) Anatomy medicine.symptom Nerve Net business resting-state fMRI 030217 neurology & neurosurgery Research Article |
| Zdroj: | Human Brain Mapping Human brain mapping 41(4), 994-1005 (2020). doi:10.1002/hbm.24855 |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.24855 |
| Popis: | Sleep deprivation (SD) could amplify the temporal fluctuation of spontaneous brain activities that reflect different arousal levels using a dynamic functional connectivity (dFC) approach. Therefore, we intended to evaluate the test–retest reliability of dFC characteristics during rested wakefulness (RW), and to explore how the properties of these dynamic connectivity states were affected by extended durations of acute sleep loss (28/52 hr). We acquired resting‐state fMRI and neuropsychological datasets in two independent studies: (a) twice during RW and once after 28 hr of SD (n = 15) and (b) after 52 hr of SD and after 14 hr of recovery sleep (RS; n = 14). Sliding‐window correlations approach was applied to estimate their covariance matrices and corresponding three connectivity states were generated. The test–retest reliability of dFC properties demonstrated mean dwell time and fraction of connectivity states were reliable. After SD, the mean dwell time of a specific state, featured by strong subcortical–cortical anticorrelations, was significantly increased. Conversely, another globally hypoconnected state was significantly decreased. Subjective sleepiness and objective performances were separately positive and negative correlated with the increased and decreased state. Two brain connectivity states and their alterations might be sufficiently sensitive to reflect changes in the dynamics of brain mental activities after sleep loss. |
| Databáze: | OpenAIRE |
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