Cobalt and its compounds: update on genotoxic and carcinogenic activities

Autor:	G. Van Maele-Fabry, Dominique Lison, S van den Brule
Přispěvatelé:	UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Centre de toxicologie clinique
Rok vydání:	2018
Předmět:	tumors 0301 basic medicine Carcinogenesis Carcinogenicity Tests Respiratory System implants DNA repair chemistry.chemical_element Bioaccessibility free radicals Pharmacology Toxicology hip prosthesis 03 medical and health sciences Metallic materials Humans humans Mode of action labeling Carcinogen topoisomerase Surface corrosion Inhalation Mutagenicity Tests occupational exposure Cobalt Environmental Exposure Nanostructures 030104 developmental biology classification chemistry Solubilization Toxicity Carcinogens DNA damage nanoparticles solubilization DNA Damage
Zdroj:	Critical reviews in toxicology, Vol. 48, no. 7, p. 522-539 (2018)
ISSN:	1547-6898 1040-8444
Popis:	This article summarizes recent experimental and epidemiological data on the genotoxic and carcinogenic activities of cobalt compounds. Emphasis is on the respiratory system, but endogenous exposure from Co-containing alloys used in endoprostheses, and limited data on nanomaterials and oral exposures are also considered. Two groups of cobalt compounds are differentiated on the basis of their mechanisms of toxicity: (1) those essentially involving the solubilization of Co(II) ions, and (2) metallic materials for which both surface corrosion and release of Co(II) ions act in concert. For both groups, identified genotoxic and carcinogenic mechanisms are non-stochastic and thus expected to exhibit a threshold. Cobalt compounds should, therefore, be considered as genotoxic carcinogens with a practical threshold. Accumulating evidence indicates that chronic inhalation of cobalt compounds can induce respiratory tumors locally. No evidence of systemic carcinogenicity upon inhalation, oral or endogenous exposure is available. The scarce data available for Co-based nanosized materials does not allow deriving a specific mode of action or assessment for these species.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb77eae5a871a773c037d358924d1c0 https://doi.org/10.1080/10408444.2018.1491023 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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