Benzodiazepine abuse, misuse, dependence, and withdrawal among schizophrenic patients: A review of the literature
| Autor: | Carlos Roncero, Nerea M. Casado-Espada, Javier I. de la Iglesia-Larrad, Ana Maciá-Casas, Rubén de Alarcón, Carmen Barral, Begoña Vicente Hernandez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Substance-Related Disorders media_common.quotation_subject Population MEDLINE Benzodiazepines 03 medical and health sciences 0302 clinical medicine Prevalence Humans Medicine Psychiatry education Biological Psychiatry media_common education.field_of_study biology business.industry Addiction Mortality rate Cognition biology.organism_classification medicine.disease Substance Withdrawal Syndrome 030227 psychiatry Substance abuse Psychiatry and Mental health Schizophrenia Female Schizophrenic Psychology Cannabis business 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research. 284:112660 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2019.112660 |
| Popis: | Patients diagnosed with schizophrenia are at least three times more likely to develop a substance use disorder than controls. These patients are frequently prescribed benzodiacepines as a coadjuvant drug, which have a high potential for addiction. We performed a literature review aiming to gather evidence on various topics concerning the use of benzodiacepines in schizophrenia, with a focus on possible abuse: 1) Prevalence of prescripted and non-prescripted benzodiacepine use among patients, 2) Prevalence of abusers, 3) Effects of long-term benzodiacepine abuse in schizophrenia prognosis, 4) Possible management strategies for benzodiacepine abuse in this population. Our search revealed there is a high variability (up to 20%) in benzodiacepine abuse among patients, with cannabis and stimulants being more frequent, and no clear demographic traits have been identified among these patients. Patients with affective symptoms are more likely to abuse benzodiazepines. Its long-term effects on prognosis have been debated, with some papers hinting at a higher mortality rate. Tapering benzodiacepines has been associated with an improvement in some cognitive functions. Management strategies for potential abuse do not differ greatly for this population, and no specific pharmacological aid can be indicated, but an integral approach is proposed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect