Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats
| Autor: | Satoshi Togashi, Sai Masahiko, Yumi Katano, Nozomi Gotoh, Hiroko Maruki-Uchida, Tatsuhiko Ito, Sumika Kanno, Yoshitaka Aso, Akira Ishihata |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cardiac function curve Male medicine.medical_specialty Heart Ventricles Diet High-Fat Muscle hypertrophy 03 medical and health sciences chemistry.chemical_compound Random Allocation Non-alcoholic Fatty Liver Disease Internal medicine Stilbenes medicine Animals Aorta Hypolipidemic Agents Piceatannol Triglyceride medicine.diagnostic_test Lipotropic Agents business.industry Cholesterol Passiflora Plant Extracts General Medicine Organ Size Rats Inbred F344 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Liver Cardiovascular Diseases Dietary Supplements Seeds Vascular resistance Vascular Resistance business Lipid profile Hepatic fibrosis Platelet Aggregation Inhibitors Food Science |
| Zdroj: | Foodfunction. 7(9) |
| ISSN: | 2042-650X |
| Popis: | The effects of chronic administration of piceatannol-enriched (9.5% w/w) passion fruit seed extract (PFSE) on the cardiovascular damage induced in a high-fat (HF) diet-fed model of Fischer 344 rats were evaluated. Rats were fed the control, HF, or HF diets containing PFSE (0.5% w/w) for 16 weeks, and the effects of the various diets on the tissue weight, serum lipid profile, hepatic fibrosis, hepatic ductular reaction, cardiac function and aortic ring reactivity were examined. HF diet-fed rats developed signs of cardiovascular disease with abnormal serum profiles compared to control diet-fed rats. PFSE supplementation improved the liver hypertrophy and hepatic histology of the HF diet-fed rats. In addition, the triglyceride and cholesterol levels, platelet aggregation, cardiac function, and acetylcholine-mediated relaxation of the aortic ring were improved. These results suggest that the chronic intake of PFSE containing piceatannol prevents HF diet-induced cardiovascular disease in rats. |
| Databáze: | OpenAIRE |
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