Identification and quantification of gallotannins in mango (Mangifera indica L.) kernel and peel and their antiproliferative activities
| Autor: | Guibing Hu, Chongde Sun, Shuxia Yan, Fenglei Luo, Guodi Huang, Yingying Fu, Xian Li, Xuming Huang, Kunsong Chen, Yu Xiang |
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| Rok vydání: | 2014 |
| Předmět: |
Nutrition and Dietetics
Antioxidant Gallotannins genetic structures Nutrition. Foods and food supply DPPH medicine.medical_treatment Antiproliferative activities food and beverages Medicine (miscellaneous) HEXA Kernel chemistry.chemical_compound Peel chemistry Biochemistry Polyphenol medicine Mangifera indica L TX341-641 Mangifera Food science Gallic acid Food Science |
| Zdroj: | Journal of Functional Foods, Vol 8, Iss, Pp 282-291 (2014) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2014.03.030 |
| Popis: | Mango (Mangifera indica L.) fruit is rich in polyphenolic compounds. Identification of individual gallotannins and evaluation of antiproliferative activities of gallotannin-rich extracts from kernel and peel of three Chinese mango cultivars were carried out in the present study. Five gallotannins, i.e. penta-, hexa-, hepta-, octa-, and nona-O-galloyl-glucoside were isolated and identified by LC-ESI-MS/MS and NMR, and quantified by HPLC. Mango kernel was a much richer source of gallotannins than its peel, and its antiproliferative effects on MDA-MB-231 breast, HepG2 liver, and HL-60 leukemia cancer cells were reported for the first time. DPPH• scavenging and antiproliferative activities of the mango kernel and peel extracts may be partially caused by penta-O-galloyl-glucoside or its analogs with different galloyl groups since penta-O-galloyl-glucoside and gallic acid also revealed high antioxidant and antiproliferative activities. Therefore, the gallotannin-rich extracts of mango kernel and peel may serve as natural sources of anticancer agents and may have important pharmaceutical potential. |
| Databáze: | OpenAIRE |
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