Increase in Short-Interval Intracortical Facilitation of the Motor Cortex after Low-Frequency Repetitive Magnetic Stimulation of the Unaffected Hemisphere in the Subacute Phase after Stroke
| Autor: | Theo Marins, Sarah Monteiro dos Anjos, Waldyr Rodrigues, Eduardo A. Mello, Corina Aparecida Fernandes, Fernanda Tovar Moll, Leonardo G. Cohen, Juliana Conti, Adriana Bastos Conforto, Karina Nocelo Ferreiro de Andrade |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Article Subject medicine.medical_treatment Stimulation Functional Laterality lcsh:RC321-571 Glutamatergic Physical medicine and rehabilitation medicine Humans Muscle Skeletal Stroke lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Rehabilitation Motor Cortex Stroke Rehabilitation Middle Aged medicine.disease Evoked Potentials Motor Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Treatment Outcome Neurology Intracortical facilitation Clinical Study Disease Progression GABAergic Female Neurology (clinical) Psychology human activities Motor cortex |
| Zdroj: | Neural Plasticity, Vol 2015 (2015) Neural Plasticity |
| ISSN: | 1687-5443 2090-5904 |
| Popis: | Low-frequency repetitive transcranial magnetic stimulation of the unaffected hemisphere (UH-LF-rTMS) in patients with stroke can decrease interhemispheric inhibition from the unaffected to the affected hemisphere and improve hand dexterity and strength of the paretic hand. The objective of this proof-of-principle study was to explore, for the first time, effects of UH-LF-rTMS as add-on therapy to motor rehabilitation on short-term intracortical inhibition (SICI) and intracortical facilitation (ICF) of the motor cortex of the unaffected hemisphere (M1UH) in patients with ischemic stroke. Eighteen patients were randomized to receive, immediately before rehabilitation treatment, either active or sham UH-LF-rTMS, during two weeks. Resting motor threshold (rMT), SICI, and ICF were measured inM1UHbefore the first session and after the last session of treatment. There was a significant increase in ICF in the active group compared to the sham group after treatment, and there was no significant differences in changes in rMT or SICI. ICF is a measure of intracortical synaptic excitability, with a relative contribution of spinal mechanisms. ICF is typically upregulated by glutamatergic agonists and downregulated by gabaergic antagonists. The observed increase in ICF in the active group, in this hypothesis-generating study, may be related toM1UHreorganization induced by UH-LF-rTMS. |
| Databáze: | OpenAIRE |
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