(+)-Nantenine isolated from Nandina domestica Thunb. inhibits adrenergic pressor responses in pithed rats
| Autor: | Hisatoshi Tsuchida, Yasushi Ohizumi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Agonist
Male Sympathetic nervous system medicine.medical_specialty Aporphines Sympathetic Nervous System Time Factors medicine.drug_class Guinea Pigs Adrenergic Stimulation Blood Pressure In Vitro Techniques Norepinephrine (medication) chemistry.chemical_compound Norepinephrine Phenylephrine Vas Deferens Internal medicine medicine Animals Rats Wistar 5-HT receptor Pharmacology Decerebrate State Dose-Response Relationship Drug Nantenine Berberidaceae Electric Stimulation Rats medicine.anatomical_structure Endocrinology chemistry Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-1 Receptor Agonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | European journal of pharmacology. 477(1) |
| ISSN: | 0014-2999 |
| Popis: | The effects of (+)-nantenine on various pressor responses, recently reported exerting competitive antagonistic activity at the alpha1-adrenoceptor/5-hydroxytryptamine (5-HT)2A receptor, were examined in vivo. (+)-Nantenine (0.03-3 mg/kg) caused a dose-dependent inhibition of the pressor response to phenylephrine (alpha1-adrenoceptor agonist) or 5-HT (5-HT receptor agonist) in both anesthetized and pithed rats. The pressor response to UK 14304 (5-Bromo-N-[2-imidazolin-2-yl]-6-quinoxalinamine) (an alpha2-adrenoceptor agonist) was inhibited by (+)-nantenine (0.003-3 mg/kg) in pithed rats in a dose-dependent manner without affecting the angiotensin II-induced pressor response in anesthetized rats. The pressor response to sympathetic nerve stimulation was also inhibited by (+)-nantenine (0.3-3 mg/kg) in a dose-dependent manner. (+)-Nantenine (3 mg/kg) facilitated the norepinephrine release induced by sympathetic nerve stimulation in pithed rats. In the guinea pig vas deferens, the initial component of contractions induced by electrical field stimulation was enhanced by (+)-nantenine (1-30 microM) in a concentration-dependent manner, while the later component was inhibited by it. These data suggest that (+)-nantenine has antagonistic activities on alpha1-adrenoceptors, alpha2-adrenoceptors and 5-HT2A receptors in pithed rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect