A review of the impact of xenobiotics from dietary sources on infant health: Early life exposures and the role of the microbiota
| Autor: | M. Calatayud Arroyo, A. Arias Borrego, B. Callejón Leblic, Maria Carmen Collado, T. García Barrera |
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| Přispěvatelé: | European Commission, Fundación Ramón Areces, Junta de Andalucía, Ministerio de Economía y Competitividad (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
010504 meteorology & atmospheric sciences Health Toxicology and Mutagenesis Population Breastfeeding Infant health 010501 environmental sciences Toxicology 01 natural sciences Xenobiotics chemistry.chemical_compound Pregnancy Environmental health medicine Humans Xenobiotic Infant Health education Child 0105 earth and related environmental sciences 2. Zero hunger education.field_of_study business.industry Microbiota Human microbiome Infant Newborn Infant General Medicine medicine.disease Pollution Early life 3. Good health Diet Breast Feeding chemistry Female business Risk assessment |
| Zdroj: | Environmental Pollution |
| Popis: | Xenobiotics are worldwide distributed and humans are unavoidably exposed to multiple chemical compounds during life, from preconception to adulthood. The human microbiota is mainly settled during early life and modulate host health and fitness. One of the main routes for chemical exposure is by intake of contaminated food and water. Thus, the interplay between diet-xenobiotics-microbiota during pregnancy and perinatal period may have relevant consequences for infant and adult health. Maternal exposure to metal(oid)s, persistent organic pollutants, and some food additives can modify the infant’s microbiota with unknown consequences for child or adult health. Toxicants’ exposure may also modulate the maternal transfer of microorganisms to the progeny during birth and breastfeeding; however, scarce information is available. The rapid increase in releasing novel chemicals to the environment, the exposure to chemical mixtures, the chronic/low dose scenario, and the delay in science-stakeholders action call for novel and groundbreaking approaches to improve a comprehensive risk assessment in sensitive population groups like pregnant women and neonates, with emphasis on microbiota as modulating factor and target-organ of xenobiotic’s toxicity. Collado M.C. and Calatayud Arroyo M acknowledge the support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC starting grant, n° 639226) and the Project from The Ramón Areces Foundation (ref. CIVP19A5918). García Barrera T., Callejón Leblic B. and Arias Borrego A. have been supported by the projects UHU-1256905 from the FEDER Andalusian operative program (Regional Ministry of Economy, Knowledge, Business and University, Andalusia, Spain) and PGC 2018-096608-B-C21 from the Spanish Ministry of Economy and Competitiveness (MINECO) |
| Databáze: | OpenAIRE |
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