Treatment effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on autoimmune MRL/MP-lpr/lpr mice
| Autor: | Takuya Kawakita, Nan-nan Zhou, Mikio Oka, Kazuko Matsuura, Kikuo Nomoto, Shoji Nakai, Yuji Saito, Hideyuki Nagasawa, Akira Suzuki, Kunisuke Himeno |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Ratón Kampo Immunology Population Spleen Thymus Gland urologic and male genital diseases law.invention Autoimmune Diseases Mice immune system diseases law medicine Animals skin and connective tissue diseases education Lymphatic Diseases Pharmacology Autoimmune disease education.field_of_study Mice Inbred C3H business.industry medicine.disease Mice Mutant Strains Proteinuria medicine.anatomical_structure Antibodies Antinuclear Splenomegaly Female Lymph Phytotherapy business CD8 Drugs Chinese Herbal |
| Zdroj: | International journal of immunopharmacology. 15(5) |
| ISSN: | 0192-0561 |
| Popis: | Autoimmune MRL /lpr mice were i.p. treated with 200 mg/kg Ren-shen-yang-rong-tang (Japanese name: Ninjin-youei-to, NYT), a traditional Chinese herbal medicine (Japanese name: Kampo), from 8 weeks of age every 3 days before the onset of autoimmune disease. Compared to age-matched control MRL /lpr mice, the serum IL-6 concentration in NYT-treated mice was decreased, their serum IFN-γ concentration was increased, and the proliferative responses of whole and enriched CD4 + cells in their spleen and lymph nodes stimulated with ConA in vitro were restored. FACS analysis revealed that the rate of decreased CD4 + CD8 + T-cell population in the thymus was decreased in MRL /lpr mice but recovered by NYT treatment. Further, adult thymectomized (ATX) MRL /lpr mice were treated with 200 mg/kg NYT similarly. NYT treatment prolonged the survival of sham-operated MRL /lpr mice and ameliorated their proteinuria but did not improve such autoimmune manifestations in ATX-MRL /Ipr mice. These findings suggest that NYT plays an important role in the abrogation of autoimmune-prone T cell differentiation and that the therapeutic effect of NYT is dependent on the thymus in MRL /Ipr mice. |
| Databáze: | OpenAIRE |
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